Comprimés de Nortriptyline
Revu par Sid DajaniDernière mise à jour par Michael Stewart, MRPharmSDernière mise à jour 19 sept. 2023
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Gardez vos rendez-vous réguliers avec votre médecin. Cela permet à votre médecin de suivre vos progrès.
The tablets could make you feel sleepy. If this happens, do not drive and do not use tools or machines. Do not drink alcohol.
Informez votre médecin si vous ressentez des effets secondaires gênants.
En un coup d'œil
Nortriptyline is a medicine used to treat depression, and sometimes nerve pain.
It is available as tablets, capsules, and an oral liquid.
Take your dose as prescribed by your doctor, usually multiple times a day or once at bedtime.
It can take 4-6 weeks to feel the full benefit when treating depression.
Common side-effects include dry mouth, constipation, and feeling sleepy.
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About nortriptyline
Type de médicament | Un antidépresseur tricyclique |
Utilisé pour | Treatment of depression |
Disponible sous forme de | Comprimés, capsules et médicaments liquides oraux |
Nortriptyline belongs to a group of medicines known as antidépresseurs tricycliques. It is prescribed for the treatment of dépression. Depression can develop for no apparent reason, or it may be triggered by a life event such as a relationship problem, bereavement, or illness. People with depression have a consistently low mood and other symptoms severe enough to interfere with normal day-to-day activities.
Nortriptyline is thought to work by interfering with certain brain chemicals (called neurotransmitters) which may be involved in causing the symptoms of depression.
Although nortriptyline is only licensed for use in depression, it is also commonly prescribed to help ease certain types of nerve pain. If you have been prescribed nortriptyline for this reason, then you should ask your doctor if you have any questions about your treatment.
Before taking nortriptyline
Retour au sommaireSome medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking nortriptyline it is important that your doctor knows:
Si vous êtes enceinte ou si vous allaitez.
Si vous avez une glande thyroïde hyperactive.
Si vous avez un problème avec le fonctionnement de votre foie.
Si vous avez de l'épilepsie.
Si vous avez un taux de sucre dans le sang élevé (diabète sucré).
Si vous avez eu des problèmes de constipation.
Si vous avez des difficultés à uriner, ou si vous avez eu des problèmes de prostate.
If you have a heart disorder or blood vessel disease.
Si vous avez déjà eu un problème de santé mentale (en particulier, un trouble bipolaire ou une psychose).
If you have increased pressure in your eyes, a condition called glaucoma.
If you have been told you have a tumour on your adrenal gland, called phaeochromocytoma.
Si vous avez un trouble sanguin héréditaire rare appelé porphyrie.
If you are taking other medicines, including those available to buy without a prescription, as well as herbal and complementary medicines. This is especially important if you have recently taken a medicine for depression, known as a monoamine-oxidase inhibitor (MAOI).
Si vous avez déjà eu une réaction allergique à un médicament.
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How to take nortriptyline
Retour au sommaireBefore you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about nortriptyline and will provide you with a full list of the side-effects which you may experience from taking it.
It is usual to take three or four doses of nortriptyline a day, although it can also be prescribed as a single dose to be taken at bedtime. The directions for taking it will be printed on the label of the pack to remind you what the doctor said to you. If you have any questions about what dose to take, ask your pharmacist for advice.
Your doctor is likely to prescribe you a small dose when you first start taking it, and then increase your dose gradually as your body gets used to it.
Many people find if helps to swallow the tablets with a drink of water. You can take nortriptyline before or after meals.
If you forget to take a dose, take one as soon as you remember. If when you remember, it is nearly time for your next dose then leave out the missed dose and take your next dose when it is due. Do not take two doses together to make up for a forgotten dose.
Tirer le meilleur parti de votre traitement
Retour au sommaireEssayez de respecter vos rendez-vous réguliers avec votre médecin. Cela permet à votre médecin de suivre vos progrès.
If you are taking nortriptyline for depression, you may feel that it is not working for you straightaway. It can take a week or two for the effect to build up, and 4-6 weeks before you feel the full benefit. It is important that you do not stop taking it thinking it is not helping. Also, while you feel depressed, you may have distressing thoughts, and think about harming yourself or ending your life. If this happens, it is very important that you tell your doctor about it straightaway. There are several types of antidepressants - each type works in a slightly different way and can have different side-effects. If you find that nortriptyline does not suit you then let your doctor know, as another antidepressant may be found that does.
Your doctor will recommend that you do not drink alcohol while you are on nortriptyline. This is because it increases the risk of side-effects, such as feeling sleepy.
Some people who take nortriptyline find that their skin becomes more sensitive to sunlight than usual. Try to avoid strong sunlight until you know how your skin reacts, or use a sun cream with a high sun protection factor. Do not use sunbeds.
Your doctor may ask you to carry on taking nortriptyline even after you feel better. This is to help stop your symptoms from returning.
If you buy any medicines, check with a pharmacist that they are suitable for you to take. This is because a number of medicines can increase the risk of side-effects from nortriptyline, including some strong painkillers, flu remedies and antihistamines which can be bought from pharmacies.
If you have diabetes you may need to check your blood glucose more frequently. This is because nortriptyline can alter the levels of sugar in your blood. Your doctor will advise you about this.
If you are due to have any medical treatment, tell the person carrying out the treatment that you are taking nortriptyline as it can interfere with some anaesthetics.
Continue to take nortriptyline unless your doctor tells you otherwise. Stopping treatment suddenly can sometimes cause problems and your doctor may want you to reduce your dose gradually when this becomes necessary.
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Can nortriptyline cause problems?
Retour au sommaireAlong with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with nortriptyline. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.
Common nortriptyline side-effects | Que puis-je faire si je ressens cela ? |
Bouche sèche | Essayez de mâcher du chewing-gum sans sucre ou de sucer des bonbons sans sucre |
Constipation | Essayez de manger un régime bien équilibré contenant beaucoup de fibres et buvez beaucoup d'eau chaque jour |
Feeling sleepy, blurred vision | Do not drive and do not use tools or machines until you feel better. Do not drink alcohol |
Feeling sick (nausea), diarrhoea | Stick to simple meals - avoid rich or spicy foods. Drink plenty of water to replace lost fluids |
Feeling dizzy or light-headed when getting up | Getting up more slowly may help. If you begin to feel faint, sit down and wait until the feeling passes |
Other side-effects include feeling anxious or confused, sleeping problems, problems passing urine, tingling feelings, breast tenderness, problems when having sex, changes in appetite and weight, changes in the way things taste, ringing noise in the ears, itchy skin rash, hair loss, increased sweating, changes in heart rate or rhythm | Si l'un de ces éléments devient problématique, consultez votre médecin pour obtenir des conseils |
Si vous ressentez d'autres symptômes que vous pensez être dus aux comprimés, parlez-en à votre médecin ou à votre pharmacien pour obtenir des conseils supplémentaires.
How to store nortriptyline
Retour au sommaireGardez tous les médicaments hors de la portée et de la vue des enfants.
Conserver dans un endroit frais et sec, à l'abri de la chaleur et de la lumière directes.
Informations importantes sur tous les médicaments
Retour au sommaireInformations importantes sur tous les médicaments
Never take more than the prescribed dose. Tricyclic antidepressants can be dangerous in overdose. If you suspect that you or someone else might have taken an overdose, go to the accident and emergency department of your local hospital at once. Take the container with you, even if it is empty.
Ce médicament est pour vous. Ne le donnez jamais à d'autres personnes, même si leur état semble être le même que le vôtre.
Ne gardez pas de médicaments périmés ou indésirables. Apportez-les à votre pharmacie locale qui s'en débarrassera pour vous.
Si vous avez des questions concernant ce médicament, demandez à votre pharmacien.
Signaler les effets secondaires d'un médicament ou d'un vaccin
Si vous ressentez des effets secondaires, vous pouvez les signaler en ligne via le Site web de Yellow Card.

Vous n'êtes pas sûr de mélanger des médicaments ?
Vérifiez les interactions possibles entre les médicaments, les compléments et les aliments avant de les prendre ensemble.
Questions fréquemment posées
Can nortriptyline be used for conditions other than depression?
Yes, although nortriptyline is primarily licensed for depression, it is also commonly prescribed to help ease certain types of nerve pain. If you've been prescribed it for this reason, you should discuss any questions with your doctor.
How long does it take for nortriptyline to start working for depression?
You may not feel the effects of nortriptyline straight away for depression. It can take one to two weeks for the effect to build up, and typically four to six weeks before you experience the full benefit. It's important to continue taking it during this time.
What should I do if I forget to take a dose of nortriptyline?
If you miss a dose, take it as soon as you remember. However, if it's almost time for your next scheduled dose, you should skip the missed dose and just take your next dose when it's due. Do not take a double dose to make up for the one you missed.
Why is alcohol not recommended while taking nortriptyline?
Your doctor will likely advise you not to drink alcohol while using nortriptyline because it can increase the risk of side-effects, such as feeling sleepy.
Can nortriptyline affect my blood sugar levels if I have diabetes?
Yes, nortriptyline can alter the levels of sugar in your blood. If you have diabetes, your doctor may ask you to check your blood glucose more frequently and will provide advice on this.
Is it safe to stop taking nortriptyline once I feel better?
No, your doctor may recommend you continue taking nortriptyline even after your symptoms improve to help prevent them from returning. Stopping treatment suddenly can cause problems, and your doctor may want to reduce your dose gradually when it's time to stop.
Are there any over-the-counter medicines I should be careful with while taking nortriptyline?
Yes, a number of medicines, including some strong painkillers, flu remedies, and antihistamines available from pharmacies, can increase the risk of side-effects from nortriptyline. Always check with a pharmacist to ensure any over-the-counter medicines are suitable for you.
Lectures complémentaires et références
- Manufacturer's PIL, Nortriptyline 10 mg, 25 mg and 50 mg film-coated Tablets; ADVANZ Pharma, The electronic Medicines Compendium. Dated November 2021.
- Médicaments Complets BNF 89e Édition; Association Médicale Britannique et Société Royale Pharmaceutique de Grande-Bretagne, Londres.
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À propos de l'auteurVoir la biographie complète

Michael Stewart, MRPharmS
Responsable de l'examen des notices de médicaments – Contractuel, Pharmacien
BPharm (Hons), MRPharmS
Michael est un pharmacien communautaire exerçant dans les Midlands et le South Yorkshire avec plus de 20 ans d'expérience dans le conseil sur les médicaments et les conditions médicales. Il possède une solide expérience en formation dans le domaine de la santé, ayant produit et dispensé des cours de formation pour les équipes de pharmacie et le personnel des établissements de soins résidentiels, y compris les infirmières. Il a également contribué aux comités consultatifs de pharmacie pour la gestion des affections de faible gravité dans la communauté.
À propos du critique

Sid Dajani
Sultan Dajani a obtenu son diplôme à la London School of Pharmacy en 1994 et est devenu le plus jeune membre élu du conseil de la Royal Pharmaceutical Society depuis sa fondation en 1842.
Historique de l'article
Les informations sur cette page sont rédigées et examinées par des cliniciens qualifiés.
Prochaine révision prévue : 18 sept. 2026
19 sept. 2023 | Dernière version

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