Duloxétine pour les troubles de l'humeur et nerveux
Cymbalta, Depalta, Duciltia
Revu par Dr Colin Tidy, MRCGPDernière mise à jour par Michael Stewart, MRPharmSLast updated 17 août 2024
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Duloxetine (Cymbalta®, Depalta® and Duciltia®) is prescribed to treat mood and nerve disorders. You may also be prescribed generic duloxetine capsules.
30 mg and 60 mg dosages are usually given for the treatment of depression, anxiety, and nerve pain.
Each time you collect a prescription from the pharmacy make sure the strength of your medicine (30 mg or 60 mg) is the same as before. Ask your pharmacist if you have any questions or concerns.
Common side effects of duloxetine include feeling sick (nausea), dry mouth, headache, constipation, and diarrhoea. Duloxetine can also make you feel dizzy or sleepy. If this happens, do not drive and do not use tools or machines.
Please tell your doctor if you feel that you are getting worse, or if you experience any troublesome side effects.
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About duloxetine
Type de médicament | A serotonin and noradrenaline reuptake inhibitor |
Utilisé pour | Depression; anxiety disorder; pain caused by nerve damage in people with diabetes |
Aussi appelé | Cymbalta®; Depalta®; Duciltia® |
Disponible sous forme de | Capsules |
What is duloxetine used for?
Retour au sommaireDuloxetine is a type of antidepressant called a serotonin and noradrenaline reuptake inhibitor (SNRI). It is used to treat dépression, troubles anxieux, and pain caused by nerve damage in people with diabetes, called diabetic neuropathy.
Duloxetine is thought to work by regulating the levels of certain chemicals in your brain, called serotonin and noradrenaline/norepinephrine, helping to improve symptoms of depression, anxiety, and nerve pain.
Other uses
Duloxetine is also prescribed for treating urinary symptoms, although a different brand and strength of capsule are used. There is a separate medicine leaflet called Duloxétine pour les symptômes urinaires, giving more information about duloxetine when used for this condition.
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Side effects of duloxetine
Retour au sommaireThe most common side effects of duloxetine are:
Se sentir mal.
Bouche sèche.
Constipation.
Diarrhée.
Feeling dizzy, tired or sleepy.
Maux de tête.
Sueurs.
Feeling anxious or shaky.
Problèmes de sommeil.
Reduced sex drive (libido).
You will find a full list in the manufacturer's information leaflet supplied with your medicine.
Les effets indésirables s'améliorent souvent à mesure que votre corps s'adapte au nouveau médicament, mais parlez à votre médecin ou pharmacien si l'un des effets suivants persiste ou devient gênant.
How to manage duloxetine side effects
Retour au sommaireVery common duloxetine side effects (these affect more than 1 in 10 people) | Que puis-je faire si je ressens cela ? |
Se sentir malade | Mangez des repas simples - évitez les aliments riches ou épicés |
Bouche sèche | Essayez de mâcher du chewing-gum sans sucre ou de sucer des bonbons sans sucre |
Constipation | Essayez de manger un régime équilibré et de boire plusieurs verres d'eau chaque jour |
Common duloxetine side effects (these affect fewer than 1 in 10 people) | Que puis-je faire si je ressens cela ? |
Blurred vision; feeling tired, dizzy or sleepy | Do not drive and do not use tools or machines while affected. Avoid alcohol |
Diarrhée | Buvez beaucoup d'eau pour remplacer les fluides perdus |
Maux de tête | Buvez beaucoup d'eau et demandez à votre pharmacien de vous recommander un antidouleur approprié. Si les maux de tête persistent, informez votre médecin |
Lack of appetite, indigestion, stomach pain, facial flushing, increased blood pressure, difficulty sleeping, feeling anxious, skin tingling, feeling shaky, reduced interest in sex, increased sweating | Discutez-en avec votre médecin si l'un d'eux devient gênant |
Important : if you develop any depressing or distressing thoughts or ideas, you should let your doctor know about this as soon as possible. When this medicine is prescribed for people with depression or anxiety, it can increase the risk of suicidal thoughts, particularly when the treatment is first started.
Dans de rares cas, des médicaments qui affectent le niveau de sérotonine dans le cerveau peuvent le faire augmenter excessivement et provoquer des problèmes. Le risque est plus élevé si vous prenez un autre médicament ayant cet effet (comme un antidépresseur). Consultez un médecin si vous développez l'une des combinaisons suivantes :
Muscles raides ou mouvements 'saccadés'.
Rythme cardiaque inhabituellement rapide.
Température élevée (fièvre).
Se sentir mal (nausée) ou vomir, diarrhée.
Se sentir délirant ou voir des visions (halluciner).
If you experience any other symptoms which you think may be due to the medicine, please speak with your doctor or pharmacist for further advice
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Who should not take duloxetine?
Retour au sommaireSome medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking duloxetine it is important that your doctor knows:
Si vous êtes enceinte, essayez d'avoir un bébé ou allaitez.
If you have problems with the way your liver works, or with the way your kidneys work.
Si vous avez une maladie cardiaque.
If you have increased eye pressure (called glaucoma).
Si vous avez de l'hypertension.
If you have ever had 'high' moods, such as mania in bipolar disorder.
If you have ever had a fit (seizure).
If you have a blood disorder that increases your risk of bleeding.
Si vous prenez ou utilisez d'autres médicaments. Cela inclut tous les médicaments que vous prenez et qui sont disponibles à l'achat sans ordonnance, ainsi que les médicaments à base de plantes et complémentaires.
Si vous avez déjà eu une réaction allergique à un médicament.
How to take duloxetine
Retour au sommaireRead the manufacturer's printed information leaflet from inside the pack. It will give you more information about duloxetine and will provide you with a full list of the side effects which you may experience from taking it.
Take duloxetine exactly as your doctor tells you to. The usual dose is one capsule of either 30 mg or 60 mg daily.
When starting duloxetine, your doctor may give you the lower strength of capsules to begin with, and then increase the strength as you go on.
Try to take your doses at the same time of day each day, as this will help you to remember to take your doses regularly.
You can take duloxetine either before or after meals. Swallow the capsule whole with a drink of water to help you to swallow it.
If you forget to take a dose at your usual time, take it when you remember. If you do not remember until the following day then leave out the forgotten dose and take your next dose when it is due. Do not take two doses together to make up for a missed dose.
Tirer le meilleur parti de votre traitement
Retour au sommaireEssayez de respecter vos rendez-vous réguliers avec votre médecin. Cela permet à votre médecin de suivre vos progrès et de revoir votre traitement.
You may feel that duloxetine is not helping you straightaway. If you are taking duloxetine for depression or anxiety, it can take a week or two before the effect builds up and 2-4 weeks before you feel the full benefit.
If you are taking duloxetine for nerve pain damage, it can take several weeks before you feel better. Do not stop taking the capsules after a week or so, even if you think they are not working.
If you are taking duloxetine for depression, you should expect that a normal course of treatment will last for around six months after your symptoms have eased.
There are several types of antidepressants and they differ in their possible side effects - if you find that duloxetine does not suit you then let your doctor know, as another may be found that will.
If you drink alcohol, ask your doctor for advice about drinking while you are on duloxetine. Drinking alcohol can increase the risk of unwanted effects from duloxetine, such as dizziness and blurred vision.
If you buy any medicines, check with a pharmacist that they are suitable to take with duloxetine. This is because some herbal medicines (such as St John's wort) can increase the risk that you will experience unwanted effects.
If you are having an operation or dental treatment, please tell the person carrying out the treatment that you are taking duloxetine.
Keep taking duloxetine until your doctor tells you otherwise. Your treatment is likely to last for a number of months.
Stopping suddenly can cause symptoms such as headache, sickness, anxiety, dizziness, shakiness and sleeping problems. Your doctor will reduce your dose gradually over a week or two to reduce the risk of these sorts of problems.
How to store duloxetine
Retour au sommaireGardez tous les médicaments hors de la portée et de la vue des enfants.
Conserver dans un endroit frais et sec, à l'abri de la chaleur et de la lumière directes.
Informations importantes sur tous les médicaments
Retour au sommaireInformations importantes sur tous les médicaments
Ne prenez jamais plus que la dose prescrite. Si vous soupçonnez que vous ou quelqu'un d'autre avez pris une surdose de ce médicament, rendez-vous au service des urgences de votre hôpital local. Emportez le contenant avec vous, même s'il est vide.
Ce médicament est pour vous. Ne le donnez jamais à d'autres personnes, même si leur état semble être le même que le vôtre.
Ne gardez pas de médicaments périmés ou indésirables. Apportez-les à votre pharmacie locale qui s'en débarrassera pour vous.
Si vous avez des questions concernant ce médicament, demandez à votre pharmacien.
Signaler les effets secondaires d'un médicament ou d'un vaccin
Si vous ressentez des effets secondaires, vous pouvez les signaler en ligne via le Yellow Card website.
Questions fréquemment posées
Retour au sommaireDoes duloxetine cause weight gain?
Duloxetine is not strongly linked with weight gain, however some people may notice changes in their weight. It's important to speak to your doctor if you're concerned.
What is the most common side effect of duloxetine?
The most common side effect of duloxetine is feeling sick (nausea), although other issues like dry mouth or sleep changes can also occur. These side effects often go away over time.
How long can you take duloxetine for nerve pain?
How long you can take duloxetine for nerve pain depends on your individual needs and how well the medicine works for you. Some people may only need it for a few months, while others stay on it longer to keep their symptoms under control.
Is duloxetine addictive?
Duloxetine is not considered addictive. However, stopping it suddenly can cause withdrawal symptoms such as dizziness, headaches, or irritability. For this reason, your doctor will usually advise reducing the dose gradually if you decide to stop.

Vous n'êtes pas sûr de mélanger des médicaments ?
Vérifiez les interactions possibles entre les médicaments, les compléments et les aliments avant de les prendre ensemble.
Lectures complémentaires et références
- Manufacturer's PIL, Cymbalta® 30 mg hard gastro-resistant capsules, Cymbalta® 60 mg hard gastro-resistant capsules; Eli Lilly and Company Ltd, The electronic Medicines Compendium. Dated June 2024.
- Médicaments Complets BNF 89e Édition; Association Médicale Britannique et Société Royale Pharmaceutique de Grande-Bretagne, Londres.
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Historique de l'article
Les informations sur cette page sont rédigées et examinées par des cliniciens qualifiés.
Next review due: 24 Aug 2027
17 août 2024 | Dernière version

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