Injection à action prolongée de palipéridone
Xeplion, Trevicta, Byannli
Revu par Sid DajaniDernière mise à jour par Michael Stewart, MRPharmSDernière mise à jour 17 août 2024
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Paliperidone long-acting injection will be given to you by your doctor or nurse every four weeks to begin with.
If you miss an appointment for an injection, please make another appointment as soon as possible.
The most common side-effects are headache and difficulties sleeping.
En un coup d'œil
Paliperidone is an antipsychotic medicine given as a long-acting injection.
It is used for adults with schizophrenia to help regulate brain chemicals and control symptoms.
Injections are given regularly, typically once a month, with 3-monthly and 6-monthly options available.
Benefits include not having to remember to take daily tablets.
Keep all regular appointments for your injections and monitoring.
Tell your doctor if you are pregnant, have a heart condition, or other specified health issues.
Do not drink alcohol while on paliperidone as it increases the risk of side-effects.
About paliperidone long-acting injection
Type de médicament | Un médicament antipsychotique |
Utilisé pour | La schizophrénie chez les adultes |
Aussi appelé | Xeplion®; Trevicta®; Byannli® |
Disponible sous forme de | Long-acting intramuscular depot injection |
Schizophrénie is a mental health condition that causes disordered ideas, beliefs and experiences. You will have been prescribed paliperidone to relieve the symptoms of schizophrenia. Such symptoms include hearing, seeing, or sensing things that are not real, having mistaken beliefs and feeling unusually suspicious. Paliperidone works on the balance of chemical substances in your brain to help control these types of symptoms.
Long-acting or 'depot' injections are used for maintenance once your symptoms have been eased by taking tablets. The injection slowly releases paliperidone into your body. You will need to receive the injection regularly, once every month. A three-monthly injection (Trevicta®) is available for people who are stable on once-monthly injections. There is also a six-monthly injection (Byannli®). The main advantage of a depot injection is that you do not have to remember to take tablets every day.
Before having paliperidone injection
Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start having paliperidone injections, it is important that your doctor knows:
Si vous êtes enceinte ou si vous allaitez.
Si vous avez une maladie cardiaque ou une maladie des vaisseaux sanguins.
Si vous avez des problèmes de foie, de reins ou de prostate.
Si vous avez des problèmes de respiration.
If you have any of the following: epilepsy, dépression, la maladie de Parkinson, raised pressure in your eye (glaucoma) or a condition which causes muscle weakness, called myasthénie grave.
If you have ever had yellowing of your skin or the whites of your eyes (jaunisse) or a blood disorder.
If you are scheduled to have eye cataract surgery.
Si vous avez une tumeur sur votre glande surrénale (une condition appelée phéochromocytome), ou si on vous a dit que vous avez 'une tumeur dépendante de la prolactine'.
Si vous avez eu une réaction allergique à un médicament.
Si vous prenez ou utilisez d'autres médicaments. Cela inclut tous les médicaments que vous prenez et qui sont disponibles à l'achat sans ordonnance, ainsi que les médicaments à base de plantes et complémentaires.
How paliperidone long-acting injection is given
Before you start the treatment, ask to read the manufacturer's printed information leaflet from inside the pack. It will give you more information about paliperidone and it will also provide you with a full list of the side-effects which you may experience from having it.
Paliperidone injection will be given to you by your doctor or nurse. The first two doses will be injected into a muscle in your upper arm. After this, the injections can either be given into a muscle in your arm, or if preferred, the buttocks.
If you haven't received paliperidone injection before, you will initially be given a dose of 150 mg and then a dose of 100 mg a week later. From then on, you will need to have one injection each month. Your doctor will adjust the amount of paliperidone given to suit what is right for you.
When your dose of once-monthly injection is stabilised, a three-monthly injection is available and may be suitable for you.
Tirer le meilleur parti de votre traitement
Your treatment will require careful monitoring to make sure that you get the best possible benefit from paliperidone. Keep your regular doctor's appointments so that you get your injections on time and your progress can be checked. If you miss an appointment for an injection, contact your doctor to arrange for another appointment as soon as possible. This is so that you can be given the injection without any further delay.
If you are due to have any dental treatment or an operation, please tell the person carrying out the treatment that you have had a paliperidone injection. This is important because it may interfere with any anaesthetic you receive. If you are having cataract surgery, it is particularly important that you tell your surgeon that you are on paliperidone. This is because an eye problem known as 'floppy iris syndrome' has developed in some people and your doctor will want to advise you about the risks of this.
If you buy or take any 'over-the-counter' medicines, check with a pharmacist that they are suitable for you to take with paliperidone.
If you have diabetes you may need to check your blood glucose more frequently, as paliperidone may affect the levels of sugar in your blood. Your doctor will advise you about this.
If you drink alcohol, please ask your doctor for advice. Alcohol increases the risk of side-effects from paliperidone, so it is best avoided.
Can paliperidone cause problems?
Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with paliperidone long-acting injection. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.
Very common paliperidone injection side-effects (these affect more than 1 in 10 people) | Que puis-je faire si je ressens cela ? |
Difficulties sleeping | Discuss this with your doctor if it becomes troublesome |
Maux de tête | Buvez beaucoup d'eau et demandez à votre pharmacien de vous recommander un antidouleur approprié. Si les maux de tête persistent, informez votre médecin |
Common paliperidone injection side-effects (these affect fewer than 1 in 10 people) | Que puis-je faire si je ressens cela ? |
Pain at the site of the injection | This should quickly pass. If the area becomes red, swollen or 'lumpy', let your doctor know |
Feeling dizzy, tired or sleepy | Ne conduisez pas et n'utilisez pas d'outils ou de machines. Ne buvez pas d'alcool |
Feeling shaky or restless, unusual or uncontrollable movements | Parlez avec votre médecin |
Feeling sick (nausea) or being sick (vomiting), indigestion, tummy (abdominal) discomfort | Optez pour des repas simples - évitez les aliments riches ou épicés |
Diarrhée | Buvez beaucoup d'eau pour remplacer les fluides perdus |
Constipation | Buvez beaucoup d'eau et mangez un régime bien équilibré |
Increased infections, weight increase or loss, mood changes, high blood pressure, toothache, rash, aches and pains | Discutez-en avec votre médecin si l'un d'eux devient gênant |
Changes to the results of some medical tests | Votre médecin vérifiera ces éléments |
Important: si vous ressentez des symptômes tels que raideur musculaire, température très élevée (fièvre), confusion, rythme cardiaque rapide et transpiration, vous devez contacter votre médecin immédiatement. Ceux-ci peuvent être des signes d'une affection rare mais grave connue sous le nom de syndrome malin des neuroleptiques.
If you experience any other symptoms which you think may be due to the medicine, please speak with your doctor or pharmacist for further advice.
How to store paliperidone
Gardez tous les médicaments hors de la portée et de la vue des enfants.
Conserver dans un endroit frais et sec, à l'abri de la chaleur et de la lumière directes.
Informations importantes sur tous les médicaments
Informations importantes sur tous les médicaments
If you suspect that you have had an overdose of this medicine, contact your doctor or go to the accident and emergency department of your local hospital.
Si vous avez des questions concernant ce médicament, demandez à votre pharmacien.
Signaler les effets secondaires d'un médicament ou d'un vaccin
Si vous ressentez des effets secondaires, vous pouvez les signaler en ligne via le Site web de Yellow Card.

Vous n'êtes pas sûr de mélanger des médicaments ?
Vérifiez les interactions possibles entre les médicaments, les compléments et les aliments avant de les prendre ensemble.
Questions fréquemment posées
What should I do if I miss an appointment for my paliperidone injection?
It is important to contact your doctor as soon as possible to reschedule your appointment if you miss one. This ensures you receive your injection without further delay, which is crucial for the effectiveness of the treatment.
Are there any specific concerns if I have diabetes and am taking paliperidone?
Yes, if you have diabetes, you might need to check your blood glucose levels more often. Paliperidone can affect your blood sugar, so your doctor will provide specific advice on how to manage this while on the medication.
Can I take other medications, including over-the-counter or herbal remedies, while on paliperidone?
Before taking any other medicines, including those available without a prescription, or any herbal and complementary medicines, you should check with a pharmacist to ensure they are suitable to take with paliperidone. Some medications can interact negatively.
What is 'floppy iris syndrome' and why is it important to tell my surgeon about paliperidone before cataract surgery?
'Floppy iris syndrome' is an eye problem that has been observed in some people taking paliperidone. If you are having cataract surgery, it is particularly important to inform your surgeon about your medication so they can advise you on the potential risks and take necessary precautions during the procedure.
What should I do if I think I'm experiencing Neuroleptic Malignant Syndrome?
If you experience symptoms like muscle stiffness, a very high temperature (fever), confusion, a fast heartbeat, and sweating, you should contact your doctor immediately. These could be signs of a rare but serious condition called neuroleptic malignant syndrome.
Lectures complémentaires et références
- Manufacturer's PIL, Xeplion® prolonged-release suspension for injection; Janssen-Cilag Ltd, The electronic Medicines Compendium. Dated June 2023.
- Manufacturer's PIL, Trevicta® 175 mg prolonged release suspension for injection; Janssen-Cilag Ltd, The electronic Medicines Compendium. Dated June 2023.
- Médicaments Complets BNF 89e Édition; Association Médicale Britannique et Société Royale Pharmaceutique de Grande-Bretagne, Londres.
À propos de l'auteurVoir la biographie complète

Michael Stewart, MRPharmS
Responsable de l'examen des notices de médicaments – Contractuel, Pharmacien
BPharm (Hons), MRPharmS
Michael est un pharmacien communautaire exerçant dans les Midlands et le South Yorkshire avec plus de 20 ans d'expérience dans le conseil sur les médicaments et les conditions médicales. Il possède une solide expérience en formation dans le domaine de la santé, ayant produit et dispensé des cours de formation pour les équipes de pharmacie et le personnel des établissements de soins résidentiels, y compris les infirmières. Il a également contribué aux comités consultatifs de pharmacie pour la gestion des affections de faible gravité dans la communauté.
À propos du critique

Sid Dajani
Sultan Dajani a obtenu son diplôme à la London School of Pharmacy en 1994 et est devenu le plus jeune membre élu du conseil de la Royal Pharmaceutical Society depuis sa fondation en 1842.
Historique de l'article
Les informations sur cette page sont rédigées et examinées par des cliniciens qualifiés.
Article également disponible en Anglais, Allemand, Espagnol, Français, Italien, Portugais, Hindi, Hébreu, Arabe, and Suédois.
Prochaine révision prévue : 24 août 2027
17 août 2024 | Dernière version

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