Oméprazole pour réduire l'acidité gastrique
Losec, Mezzopram, Prilosec
Revu par Sid DajaniDernière mise à jour par Michael Stewart, MRPharmSDernière mise à jour 7 août 2023
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Omeprazole reduces the amount of acid produced in the stomach.
Common side effects include stomach upset and headache. These effects are generally mild and do not last long.
Some omeprazole capsules and tablets should be swallowed whole; others can be mixed with water or fruit juice to make swallowing easier - check the manufacturer's printed information leaflet from inside the pack for directions.
En un coup d'œil
Omeprazole is a proton pump inhibitor used to reduce stomach acid.
It treats conditions like acid reflux, stomach ulcers, and H. pylori infection.
It works by stopping cells in the stomach lining from producing too much acid.
Common side effects include nausea, vomiting, stomach ache, and headache.
Short courses can be bought for reflux symptoms; otherwise, it is prescription-only.
Do not stop taking omeprazole suddenly as symptoms may worsen.
About omeprazole
Type de médicament | Proton pump inhibitor |
Utilisé pour | Healing or prevention of gastric or duodenal ulcers; gastro-oesophageal reflux disease; Helicobacter pylori infection; Zollinger-Ellison syndrome; acid-related dyspepsia; reduction of gastric acid during surgery |
Aussi appelé (Royaume-Uni) | Losec®; Mezzopram®; Pyrocalm Control® |
Aussi appelé (États-Unis) | Prilosec® |
Disponible sous forme de | Capsules, tablets, dispersible tablets and injection |
What is omeprazole used for?
Omeprazole is a inhibiteur de la pompe à protons (IPP) used to reduce the amount of acid in your stomach. It is usually prescribed for the treatment of digestive conditions such as reflux acide et ulcères d'estomac.
Omeprazole is also given as one part of a treatment to get rid of Helicobacter pylori, a bacterium found in the stomach, which can cause ulcers.
Omeprazole is available on prescription. You can also buy short courses of omeprazole at a pharmacy for the treatment of reflux symptoms (such as heartburn) in adults.
How does omeprazole work?
Omeprazole works by stopping cells in the lining of the stomach from producing too much acid. This can help to prevent ulcers from forming, or assist the healing process where damage has already occurred.
By decreasing the amount of acid, they can also help to reduce the symptoms of acid reflux disease, such as heartburn.
Side effects of omeprazole
The most common side effects of omeprazole are:
Sensation de nausée.
Être malade (vomissements).
Maux d'estomac.
Farting.
Diarrhée.
Constipation.
Maux de tête.
Vous trouverez une liste complète dans la notice d'information du fabricant fournie avec votre médicament.
Les effets indésirables s'améliorent souvent à mesure que votre corps s'adapte au nouveau médicament, mais parlez à votre médecin ou pharmacien si l'un des effets suivants persiste ou devient gênant.
How to manage omeprazole side effects
Common omeprazole side effects (these affect fewer than 1 in 10 people) | Que puis-je faire si je ressens cela ? |
Stomach upset, such as feeling sick, stomach ache, or wind (flatulence); tummy (abdominal) pain, being sick | Stick to simple meals - avoid rich or spicy foods. If symptoms are severe or do not go away, let your doctor know |
Diarrhée | Drink plenty of water. If it continues or becomes severe, let your doctor know |
Constipation | Essayez de manger un régime équilibré et de boire plusieurs verres d'eau chaque jour |
Maux de tête | Drink plenty of water and ask your pharmacist to recommend a suitable painkiller. If the headaches continue let your doctor know |
Si vous ressentez d'autres symptômes que vous pensez être dus au médicament, parlez-en à votre médecin ou à votre pharmacien pour obtenir des conseils supplémentaires.
Who should not take omeprazole?
Some medicines are not suitable for people with certain conditions. Before taking omeprazole let your doctor know about any of the following:
Si vous êtes enceinte, essayez d'avoir un bébé ou allaitez.
If you have any of the following symptoms: difficulty swallowing, loss of blood, weight loss, or if you are being sick (vomiting).
Si vous avez des problèmes avec le fonctionnement de votre foie.
Si vous avez déjà eu une réaction allergique à un médicament.
Si vous prenez d'autres médicaments. Cela inclut tous les médicaments que vous prenez et qui sont disponibles à l'achat sans ordonnance, ainsi que les médicaments à base de plantes et les médecines complémentaires.
How to take omeprazole
Read the manufacturer's printed information leaflet from inside the pack. It will give you more information about omeprazole and will provide you with a full list of the side effects which you may experience from taking it.
Omeprazole tablets and capsules contain small pellets which are specially coated to make sure that the medicine is absorbed correctly by your body. Do not chew the pellets. If you find capsules or tablets difficult to swallow, let your doctor know.
Some omeprazole capsules and tablets can be mixed with water or fruit juice to make swallowing easier and your doctor can prescribe these for you.
Omeprazole can be taken before or after food, although taking it before food can be preferable.
Dosage
If you have bought omeprazole for reflux symptoms such as heartburn, take one or two (10 mg) tablets daily, preferably in a morning. You may need to take omeprazole for a day or so to control your symptoms. If your symptoms do not improve within this time, you should talk to your doctor about this.
Swallow the tablet with a drink of water - do not chew or crush the tablet before you swallow. Do not take omeprazole for more than four weeks without speaking with a doctor.
If you have been prescribed omeprazole, take it exactly as your doctor tells you to. There are different strengths of tablets and capsules available so your doctor will tell you which is right for you. It is usually taken once a day.
If you are taking it for either Helicobacter pylori eradication or for Zollinger-Ellison syndrome, it is likely you will be asked to take two doses a day. Your doctor will tell you which dose is right for you and the directions will also be on the label of the pack to remind you.
Missed dose
If you forget to take a dose at your usual time, you can take it when you remember (unless it is nearly time for your next dose, in which case leave out the missed dose).
Ne prenez pas deux doses ensemble to make up for a forgotten dose.
Tirer le meilleur parti de votre traitement
Try to keep your regular appointments with your doctor. This is so your progress can be checked. If you are taking omeprazole on a long-term basis your doctor will want to review your treatment at least once a year to make sure it is still right for you.
A typical course of treatment lasts for one or two weeks if you are taking omeprazole for Helicobacter pylori eradication. It will last for one or two months if it is to allow an ulcer to heal. For all other reasons for taking omeprazole, your treatment will last for as long as is necessary to control your symptoms.
Some foods may make your symptoms worse. Foods and drinks that have been suspected of this include peppermint, tomatoes, chocolate, spicy foods, hot drinks, coffee, and alcoholic drinks.
If it seems that a food is aggravating your symptoms, try avoiding it for a while to see if your symptoms improve.
Also, try avoiding eating large meals, as these can make your symptoms worse too.
If you are overweight, it puts extra pressure on your stomach and encourages the symptoms of acid reflux. Losing some weight and eating a healthy balanced diet may help you.
Smoking increases the amount of acid produced by the stomach and may make your symptoms worse. If you are a smoker, speak with your doctor or pharmacist about how to quit.
Recent studies suggest that there may be a slight increase in the risk of bone fractures when proton pump inhibitors like omeprazole are taken for longer than a year. If this affects you, your doctor will check that you are taking enough vitamin D and calcium to reduce this risk.
If you buy any medicines 'over the counter', always check with a pharmacist that they are safe to take alongside your other medicines.
How to store omeprazole
Gardez tous les médicaments hors de la portée et de la vue des enfants.
Conserver dans un endroit frais et sec, à l'abri de la chaleur et de la lumière directes.
Informations importantes sur tous les médicaments
Informations importantes sur tous les médicaments
Ne prenez jamais plus que la dose prescrite. Si vous soupçonnez que vous ou quelqu'un d'autre avez pris une surdose de ce médicament, rendez-vous au service des urgences de votre hôpital local. Emportez le contenant avec vous, même s'il est vide.
Ce médicament est pour vous. Ne le donnez jamais à d'autres personnes, même si leur état semble être le même que le vôtre.
Si vous subissez une opération ou un traitement dentaire, informez la personne qui effectue le traitement des médicaments que vous prenez.
Ne gardez pas de médicaments périmés ou indésirables. Apportez-les à votre pharmacie locale qui s'en débarrassera pour vous.
Si vous avez des questions concernant ce médicament, demandez à votre pharmacien.
Signaler les effets secondaires d'un médicament ou d'un vaccin
Si vous ressentez des effets secondaires, vous pouvez les signaler en ligne via le Site web de Yellow Card.
Questions fréquemment posées
How long does omeprazole take to work?
Omeprazole usually starts to work within a few hours, but it can take 1 to 4 days to notice relief from heartburn, acid reflux, stomach ulcers, or GERD. How long it takes to fully work depends on what the condition is.
Is it safe to take omeprazole during pregnancy?
Omeprazole is generally considered safe to take during pregnancy for the treatment of heartburn or acid reflux. However, it’s best to speak with your doctor or midwife before taking it to make sure it’s the right option for you and to get the correct dose.
What should be avoided when taking omeprazole?
When taking omeprazole, avoid alcohol, smoking, and spicy, fatty, or acidic foods. You should also avoid taking omeprazole with certain medicines, such as antifungals, antivirals, or blood thinners, unless your doctor advises otherwise.
What happens if I suddenly stop taking omeprazole?
If you suddenly stop taking omeprazole, your stomach may produce more acid than before, causing your symptoms to return or worsen. This is known as acid rebound and can lead to heartburn, indigestion, or acid reflux. You should reduce your dose gradually to prevent symptoms from coming back.

Vous n'êtes pas sûr de mélanger des médicaments ?
Vérifiez les interactions possibles entre les médicaments, les compléments et les aliments avant de les prendre ensemble.
Questions fréquemment posées
Can I take omeprazole if I have difficulty swallowing or other specific symptoms?
You should inform your doctor if you experience symptoms such as difficulty swallowing, loss of blood, unexplained weight loss, or persistent vomiting. These symptoms may mean that omeprazole is not suitable for you, or your doctor may need to investigate further before prescribing.
What if I miss a dose of omeprazole?
If you forget to take a dose at your usual time, you can take it when you remember. However, if it is almost time for your next scheduled dose, you should skip the missed dose and continue with your regular dosing schedule. Do not take two doses at once to make up for a forgotten dose.
How long will I need to take omeprazole?
The duration of your omeprazole treatment depends on the condition being treated. For Helicobacter pylori eradication, a typical course is one to two weeks. If it's for healing an ulcer, treatment usually lasts one to two months. For other conditions, you will take omeprazole for as long as needed to control your symptoms.
Does smoking affect omeprazole's effectiveness or my condition?
Smoking increases the amount of acid produced by the stomach, which can worsen symptoms of acid reflux and other related conditions. If you are a smoker, discussing quitting with your doctor or pharmacist may help improve your symptoms while taking omeprazole.
Are there any long-term risks associated with taking omeprazole?
Recent studies suggest that taking proton pump inhibitors like omeprazole for longer than a year may slightly increase the risk of bone fractures. If you are taking omeprazole long-term, your doctor will likely check that you are getting enough vitamin D and calcium to help reduce this risk.
How should I dispose of old or unwanted omeprazole?
Do not keep out-of-date or unwanted medicines at home. You should take them to your local pharmacy, which will dispose of them for you safely and responsibly.
Lectures complémentaires et références
- Manufacturer's PIL, Losec® Capsules 10 mg, 20 mg and 40 mg; Neon Healthcare Ltd, Le Compendium électronique des Médicaments. Daté de mars 2023.
- Manufacturer's PIL, Losec® MUPS Tablets 10 mg, 20 mg and 40 mg; Neon Healthcare Limited, The electronic Medicines Compendium. Dated March 2023.
À propos de l'auteurVoir la biographie complète

Michael Stewart, MRPharmS
Responsable de l'examen des notices de médicaments – Contractuel, Pharmacien
BPharm (Hons), MRPharmS
Michael est un pharmacien communautaire exerçant dans les Midlands et le South Yorkshire avec plus de 20 ans d'expérience dans le conseil sur les médicaments et les conditions médicales. Il possède une solide expérience en formation dans le domaine de la santé, ayant produit et dispensé des cours de formation pour les équipes de pharmacie et le personnel des établissements de soins résidentiels, y compris les infirmières. Il a également contribué aux comités consultatifs de pharmacie pour la gestion des affections de faible gravité dans la communauté.
À propos du critique

Sid Dajani
Sultan Dajani a obtenu son diplôme à la London School of Pharmacy en 1994 et est devenu le plus jeune membre élu du conseil de la Royal Pharmaceutical Society depuis sa fondation en 1842.
Historique de l'article
Les informations sur cette page sont rédigées et examinées par des cliniciens qualifiés.
Article également disponible en Anglais, Allemand, Espagnol, Français, Italien, Portugais, Hindi, Hébreu, Arabe, and Suédois.
Next review due: 6 Aug 2026
7 août 2023 | Dernière version

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