Comprimés de Quinapril
Revu par Sid DajaniDernière mise à jour par Michael Stewart, MRPharmSDernière mise à jour 15 fév 2025
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Quinapril is generally well tolerated but if you develop a troublesome cough, you must let your doctor know.
The first dose in particular can make you feel dizzy. It is best taken just before you go to sleep.
Some painkillers and indigestion remedies could interfere with quinapril. Ask your pharmacist for advice before you buy any medicines 'over the counter'.
Clinical author's note: Michael Stewart 15/11/2018: Following an MHRA update, new advice has been added to this leaflet for people also taking the blood pressure medicine hydrochlorothiazide. Hydrochlorothiazide is only available in the UK in combination with other medicines used to treat high blood pressure. It may be available on its own in other countries. For more information see the warning below in 'can this medicine cause problems?' or view the Alerte MHRA.
En un coup d'œil
Quinapril is a medicine used to treat high blood pressure and heart failure.
It works by widening blood vessels and helping to reduce excess fluid in the blood.
Take quinapril exactly as your doctor tells you, usually once daily.
Your first dose may make you feel dizzy, so consider taking it at bedtime.
Common side-effects include dizziness and a dry cough.
Stop taking quinapril and seek immediate medical help if you have swelling of your face, mouth, tongue, or throat.
About quinapril
Type de médicament | An angiotensin-converting enzyme (ACE) inhibitor |
Utilisé pour | High blood pressure (hypertension); heart failure |
Aussi appelé | Accupro® (discontinued); Accupril® (USA) |
Disponible sous forme de | Comprimés |
Quinapril belongs to a class of medicines called angiotensin-converting enzyme inhibitors, or ACE inhibitors. You may have been prescribed it to reduce hypertension artérielle (hypertension), or to treat une insuffisance cardiaque. Your doctor will tell you why it has been prescribed for you.
ACE inhibitors like quinapril prevent your body from creating a hormone known as angiotensin II. They do this by blocking (inhibiting) a chemical called angiotensin-converting enzyme. They widen your blood vessels and help to reduce the amount of water put back into your blood by your kidneys.
These actions help to decrease blood pressure. Although people with high blood pressure often do not feel unwell, if left untreated, high blood pressure can harm the heart and damage blood vessels, leading to a heart attack or stroke.
Heart failure is a condition in which your heart does not work as well as it should. Because of this, there may be too much circulating fluid in your blood vessels. Quinapril helps to reduce this. It also appears to have a protective effect on the heart.
You may be prescribed quinapril on its own, or alongside other medicines to help your condition. The brand of quinapril called Accuretic® also contains a medicine called hydrochlorothiazide. This brand can be prescribed for people with high blood pressure. Combination brands like this help to reduce the total number of tablets you need to take each day.
Before taking quinapril
Some medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. For these reasons, before you start taking quinapril it is important that your doctor knows:
Si vous êtes enceinte ou si vous allaitez.
If you have problems with the way your kidneys work, or any problems with the way your liver works.
If you are lacking in fluid in the body (dehydrated) - for example, if you have had diarrhoea or sickness very recently.
If you have been told you have a build-up of fatty deposits on the walls of your arteries, a condition called atherosclerosis.
If you have a particular type of poor circulation called peripheral arterial disease.
If you have collagen vascular disease. This includes conditions such as systemic lupus erythematosus (SLE) and scleroderma.
If you have been told you have a problem with the way your heart pumps blood
If you have been told you have heart muscle disease (cardiomyopathy), problems with the way your heart pumps blood, or narrowing of the main blood vessel from your heart (aortic stenosis).
If you have been told you have a low level of sodium in your blood.
If you have ever had a reaction where your face, tongue or throat swells (angio-oedema).
If you are having desensitisation treatment to protect against bee and wasp stings.
If you are having dialysis treatment, or treatment to remove cholesterol from your blood by a machine (LDL apheresis).
Si vous prenez d'autres médicaments. Cela inclut tous les médicaments que vous prenez et qui sont disponibles à l'achat sans ordonnance, ainsi que les médicaments à base de plantes et les médecines complémentaires.
If you have ever had an allergic or unusual reaction to any other ACE inhibitor (such as lisinopril, ramipril or enalapril), or to any other medicine.
How to take quinapril
Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about quinapril and will provide you with a full list of side-effects which you may experience from taking it.
Take the tablets exactly as your doctor tells you to. Quinapril is usually taken once daily, but it can also be prescribed as a twice-daily dose. Your dose will be printed on the label of the pack of tablets to remind you about what the doctor said to you.
Your doctor is likely to advise you to take your very first dose at bedtime. This is because the first dose can make you feel dizzy.
After the first dose, you can take quinapril at a time of day you find easy to remember, but try to take it at the same times of day each day. This will help you to remember to take your doses regularly. You can take quinapril tablets either with or without food. Swallow the tablet with a drink of water.
If you forget to take a dose, take it as soon as you remember (unless it is nearly time for your next dose, in which case leave out the missed dose and take the next dose as normal). Do not take two doses together to make up for a forgotten dose.
Tirer le meilleur parti de votre traitement
Try to keep your regular appointments with your doctor. This is so your progress can be monitored. Your doctor may want you to have some blood tests from time to time to check that your kidneys are working well.
Each time you collect a prescription, check to make sure the tablets look the same as you have had before. This is because there are several strengths of tablet. If you have any questions about your tablets, please ask your pharmacist for advice.
It is very important that you follow any dietary and lifestyle advice that you are given by your doctor. This may include advice about eating a healthy diet, not smoking, and taking regular exercise.
If you buy any medicines, check with a pharmacist that they are suitable to take with quinapril. This is because some medicines (such as anti-inflammatory painkillers and indigestion remedies) could interfere with your treatment.
It is likely that your doctor will advise that you do not use salt substitutes while you are taking quinapril. These products have a high content of potassium which could be harmful for you.
If you drink alcohol, ask your doctor for advice about drinking alcohol while you are on quinapril. Alcoholic drinks can make you feel light-headed or dizzy, and they may not be advisable for you.
If you are having an operation or dental treatment, tell the person carrying out the treatment that you are taking quinapril tablets. This is because some anaesthetics could cause your blood pressure to drop too low.
Treatment with quinapril is usually long-term unless you experience an adverse effect. Continue to take the tablets unless you are advised otherwise.
Can quinapril cause problems?
Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with quinapril. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.
Common quinapril side-effects (these affect fewer than 1 in 10 people) | Que puis-je faire si je ressens cela ? |
Feeling light-headed or dizzy, especially when standing up | Getting up more slowly should help. If you begin to feel dizzy, lie down so that you do not faint, then sit for a few moments before standing. If this continues beyond the first few days, speak with your doctor. Do not drive and do not use tools or machines while you feel dizzy |
Dry irritating cough | If this continues, speak with your doctor, as an alternative medicine may be better for you |
Maux de tête, autres douleurs et souffrances | Demandez à votre pharmacien de vous recommander un antidouleur approprié |
Feeling sick (nausea) or being sick (vomiting), indigestion, tummy (abdominal) pain, diarrhoea | Stick to simple foods - avoid rich and spicy meals |
Throat infections, runny nose, tingling feelings in your hands or toes, problems sleeping or feeling tired | Parlez à votre médecin si l'un de ces symptômes devient gênant |
Important: if you experience any of the following rare but serious symptoms, stop taking quinapril and contact your doctor for advice straightaway:
Any difficulty breathing, or swelling of your face, mouth, tongue or throat. These are signs of an allergic reaction.
Any yellowing of your skin or whites of your eyes. These may be signs of jaundice which is a rare side-effect.
Une éruption cutanée sévère.
Si vous prenez également de l'hydrochlorothiazide en combinaison avec ce médicament :
Des études ont suggéré que prendre des doses plus élevées d'hydrochlorothiazide pendant de longues périodes pourrait augmenter le risque de certains cancers de la peau.
Dites à votre médecin si vous avez déjà été traité pour un cancer de la peau auparavant.
Informez votre médecin de tout grain de beauté nouveau ou modifié, ou de toute marque inquiétante sur votre peau.
Utilisez un écran solaire en cas de fort ensoleillement. N'utilisez pas de lits de bronzage.
Si vous ressentez d'autres symptômes que vous pensez être dus aux comprimés, parlez-en à votre médecin ou à votre pharmacien pour obtenir des conseils supplémentaires.
How to store quinapril
Gardez tous les médicaments hors de la portée et de la vue des enfants.
Conserver dans un endroit frais et sec, à l'abri de la chaleur et de la lumière directes.
Informations importantes sur tous les médicaments
Informations importantes sur tous les médicaments
Ne prenez jamais plus que la dose prescrite. Si vous soupçonnez que vous ou quelqu'un d'autre avez pris une surdose de ce médicament, rendez-vous au service des urgences de votre hôpital local. Emportez le contenant avec vous, même s'il est vide.
Ce médicament est pour vous. Ne le donnez jamais à d'autres personnes, même si leur état semble être le même que le vôtre.
Ne gardez pas de médicaments périmés ou indésirables. Apportez-les à votre pharmacie locale qui s'en débarrassera pour vous.
Si vous avez des questions concernant ce médicament, demandez à votre pharmacien.
Signaler les effets secondaires d'un médicament ou d'un vaccin
Si vous ressentez des effets secondaires, vous pouvez les signaler en ligne via le Site web de Yellow Card.

Vous n'êtes pas sûr de mélanger des médicaments ?
Vérifiez les interactions possibles entre les médicaments, les compléments et les aliments avant de les prendre ensemble.
Questions fréquemment posées
What is the significance of the brand name Accupro being discontinued, and does this affect current quinapril users?
The article notes that Accupro is a discontinued brand name for quinapril. This information primarily serves to clarify that while the brand may no longer be available, the active medication, quinapril, is still in use and prescribed under different names or as a generic. It doesn't affect the availability or efficacy of quinapril for current users, who would receive it under its current brand (Accupril in the USA) or as a generic.
How does quinapril specifically protect the heart in individuals with heart failure?
In cases of heart failure, where the heart isn't working as efficiently as it should, quinapril helps by reducing the amount of circulating fluid in the blood vessels. Beyond this, the article states that quinapril also 'appears to have a protective effect on the heart,' contributing to better heart function in this condition.
What are collagen vascular diseases, and why is it important for my doctor to know if I have one before prescribing quinapril?
Collagen vascular diseases are a group of conditions that affect the body's connective tissues and can include diseases like systemic lupus erythematosus (SLE) and scleroderma. It's crucial for your doctor to be aware if you have such a condition because these illnesses can affect various organs, and quinapril's actions or potential side effects might interact in specific ways that require extra medical care or an alternative treatment.
What should I do if I am prescribed quinapril and also have a low level of sodium in my blood?
If you have a low level of sodium in your blood, it is important to inform your doctor before starting quinapril. The article highlights this as a condition requiring your doctor's awareness, suggesting that it might influence the suitability of quinapril for you or necessitate extra monitoring and care during your treatment.
If I am undergoing desensitisation treatment for bee and wasp stings, why do I need to inform my doctor before taking quinapril?
It is important to tell your doctor if you are having desensitisation treatment to protect against bee and wasp stings. The article indicates that this is a specific circumstance where your doctor needs to be aware of your medical history before prescribing quinapril, suggesting potential interactions or considerations during your treatment with both quinapril and the desensitisation therapy.
Can taking quinapril affect cholesterol-lowering treatments like LDL apheresis?
Yes, if you are undergoing treatment to remove cholesterol from your blood by a machine, known as LDL apheresis, it is important to inform your doctor. The article states this as a condition your doctor needs to know about before you start quinapril, suggesting potential interactions or requiring extra care during combined treatments.
How can I tell if a cough I'm experiencing is a common side effect of quinapril or something more serious?
A dry, irritating cough is listed as a common side effect of quinapril, affecting fewer than 1 in 10 people. If you develop a cough that continues or becomes troublesome, the article advises speaking with your doctor, as an alternative medicine might be more suitable for you. This distinguishes it from more serious reactions and offers a clear course of action.
Why is it important to check the appearance of my quinapril tablets each time I get a new prescription?
You should check the appearance of your quinapril tablets with each new prescription because there are several strengths of the tablet available. The article advises doing this to ensure you have received the correct dosage. If you notice any differences or have questions, you should ask your pharmacist for advice.
Lectures complémentaires et références
- Médicaments Complets BNF 89e Édition; Association Médicale Britannique et Société Royale Pharmaceutique de Grande-Bretagne, Londres.
À propos de l'auteurVoir la biographie complète

Michael Stewart, MRPharmS
Responsable de l'examen des notices de médicaments – Contractuel, Pharmacien
BPharm (Hons), MRPharmS
Michael est un pharmacien communautaire exerçant dans les Midlands et le South Yorkshire avec plus de 20 ans d'expérience dans le conseil sur les médicaments et les conditions médicales. Il possède une solide expérience en formation dans le domaine de la santé, ayant produit et dispensé des cours de formation pour les équipes de pharmacie et le personnel des établissements de soins résidentiels, y compris les infirmières. Il a également contribué aux comités consultatifs de pharmacie pour la gestion des affections de faible gravité dans la communauté.
À propos du critique

Sid Dajani
Sultan Dajani a obtenu son diplôme à la London School of Pharmacy en 1994 et est devenu le plus jeune membre élu du conseil de la Royal Pharmaceutical Society depuis sa fondation en 1842.
Historique de l'article
Les informations sur cette page sont rédigées et examinées par des cliniciens qualifiés.
Article également disponible en Anglais, Allemand, Espagnol, Français, Italien, Portugais, Hindi, Hébreu, Arabe, and Suédois.
Prochaine révision prévue : 15 févr. 2028
15 fév 2025 | Dernière version

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