Comprimés d'agomélatine
Valdoxan
Revu par Dr Colin Tidy, MRCGPDernière mise à jour par Michael Stewart, MRPharmSDernière mise à jour 14 avr. 2025
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Take agomelatine once a day, at bedtime.
It can take a week or two after starting the tablets before the effect builds up and you start to feel the benefit. If you do not feel you have improved after this time, go back and talk with your doctor.
The most common side effects of agomelatine are feeling dizzy or sick (nausea) - these are usually mild and soon pass.
Rarely, agomelatine can affect the way your liver works. If you develop dark urine, pale stools, any yellowing of your skin or the whites of your eyes, pain in your tummy (abdomen), or feel unusually tired, you must let your doctor know about this straightaway.
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About agomelatine
Type de médicament | A melatonin agonist |
Utilisé pour | Dépression |
Aussi appelé | Valdoxan® |
Disponible sous forme de | Comprimés |
What is agomelatine used for?
Retour au sommaireAgomelatine is an atypical antidepressant used to treat dépression.
Depression is common and symptoms can affect day-to-day life and can become very distressing. Treatments include talking (psychological) treatments and antidepressant medicines.
Our bodies follow a daily cycle, called circadian rhythms, which control sleep and other functions. When these rhythms are disrupted, it can lead to depression. Agomelatine helps depression by restoring this natural balance.
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Side effects of agomelatine
Retour au sommaireThe most common side effects of agomelatine are:
Se sentir mal.
Diarrhée.
Feeling dizzy, tired or sleepy.
Maux de tête
Constipation.
Douleurs d'estomac.
Difficulté à dormir.
Feeling anxious.
Increased sweating.
Douleur dorsale.
Vous trouverez une liste complète dans la notice d'information du fabricant fournie avec votre médicament. Les effets indésirables s'améliorent souvent à mesure que votre corps s'adapte au nouveau médicament, mais parlez-en à votre médecin ou pharmacien si l'un des effets suivants persiste ou devient gênant.
How to manage agomelatine side effects
Retour au sommaireCommon agomelatine side effects (these affect fewer than 1 in 10 people) | Que puis-je faire si je ressens cela ? |
Feeling sick, diarrhoea | Stick to simple foods (avoid fatty or spicy meals) and drink plenty of water |
Feeling dizzy, tired or sleepy | Ne conduisez pas et n'utilisez pas d'outils ou de machines. Ne buvez pas d'alcool |
Maux de tête | Drink plenty of water and ask your pharmacist to recommend a suitable painkiller. If the headache continues, speak with your doctor |
Constipation, tummy pain | Try to eat a well-balanced diet containing fresh fruit and vegetables. Drink plenty of water |
Difficulty sleeping, feeling anxious, increased sweating, back pain | These effects are usually mild and soon pass but if any become troublesome, speak with your doctor |
Important: if you notice any of the following you should contact your doctor straightaway as it could be a sign of a problem with your liver:
Dark urine or light-coloured stools.
Être malade (vomissements)
Pain in your tummy (abdomen).
Tout jaunissement de votre peau ou du blanc de vos yeux (jaunisse).
Itchy skin or unexplained bruising.
Perte d'appétit.
Any unexplained flu-like symptoms.
Feeling unusually tired or generally unwell.
Si vous ressentez d'autres symptômes que vous pensez être dus aux comprimés, parlez-en à votre médecin ou à votre pharmacien pour obtenir des conseils supplémentaires.
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Who should not take agomelatine?
Retour au sommaireSome medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. For these reasons, before you start taking agomelatine it is important that your doctor knows:
Si vous avez moins de 18 ans ou plus de 75 ans.
Si vous êtes enceinte ou si vous allaitez.
Si vous avez des problèmes avec le fonctionnement de votre foie, ou si vous avez des problèmes avec le fonctionnement de vos reins.
If you have ever had abnormally 'high' moods or dementia.
Si vous consommez régulièrement de grandes quantités d'alcool.
Si vous prenez d'autres médicaments. Cela inclut tous les médicaments disponibles à l'achat sans ordonnance, ainsi que les médicaments à base de plantes et les médecines complémentaires.
Si vous avez déjà eu une réaction allergique à un médicament.
How to take agomelatine
Retour au sommaireRead the manufacturer's printed information leaflet from inside the pack. It will give you more information about agomelatine, and will also provide you with a full list of the side effects which you could experience from taking it.
Take agomelatine exactly as your doctor tells you to. The usual dose is one tablet daily. This may be increased in some people to two tablets daily (taken together) after a couple of weeks.
You should take the tablets at bedtime. The tablets can be taken either with or without food.
If you forget to take a dose, do not worry, just take the next dose when it is due.
Tirer le meilleur parti de votre traitement
Retour au sommaireIt can take a week or two after starting the tablets before the effect begins to build up, and maybe a few weeks longer before you feel the full benefit from the treatment. Do not stop taking agomelatine after a few days, thinking it is not helping.
Try to keep your regular appointments with your doctor. This is because your doctor will want you to have a blood test every few weeks to check that your liver is staying healthy.
Your doctor will also give you a booklet to read which explains about what symptoms to look out for as signs that the medicine could be harming your liver. There is a list of these symptoms in the section below on the problems which can be caused by agomelatine.
While you feel depressed or are taking agomelatine, you may have thoughts about harming yourself or ending your life. It is very important that you tell your doctor about this straightaway if it happens to you.
Taking agomelatine and alcohol is not recommended, so do not drink alcohol during your treatment with this medicine.
Smoking can affect the amount of agomelatine in your body. Let your doctor know if you either start or stop smoking while you are taking agomelatine.
Your doctor will ask you to carry on taking agomelatine for a while after you feel better. This is to stop your symptoms from returning.
There are several types of antidepressants and they differ in their possible side effects. If you find that agomelatine does not suit you then let your doctor know, as another could be found that will suit you.
How to store agomelatine
Retour au sommaireGardez tous les médicaments hors de la portée et de la vue des enfants.
Conserver dans un endroit frais et sec, à l'abri de la chaleur et de la lumière directes.
Informations importantes sur tous les médicaments
Retour au sommaireInformations importantes sur tous les médicaments
If you buy any medicines, check with a pharmacist that they are safe to take with your prescribed medicines.
Never take more than the prescribed dose. If you suspect that you or someone else might have taken an overdose of this medicine go to the accident and emergency department of your local hospital at once. Take the container with you, even if it is empty.
Si vous subissez une opération ou un traitement dentaire, informez la personne qui effectue le traitement des médicaments que vous prenez.
Ce médicament est pour vous. Ne le donnez jamais à d'autres personnes, même si leur état semble être le même que le vôtre.
Ne gardez pas de médicaments périmés ou indésirables. Apportez-les à votre pharmacie locale qui s'en débarrassera pour vous.
Si vous avez des questions concernant ce médicament, demandez à votre pharmacien.
Signaler les effets secondaires d'un médicament ou d'un vaccin
Si vous ressentez des effets secondaires, vous pouvez les signaler en ligne via le site web Yellow Card.
Questions fréquemment posées
Retour au sommaireIs agomelatine a strong antidepressant?
Agomelatine is not considered a “strong” antidepressant in the traditional sense, but it can be effective for some people. It works differently to many other antidepressants, helping regulate sleep as well as mood.
Does agomelatine cause weight gain?
Agomelatine is less likely to cause weight gain than many other antidepressants. While changes in weight can happen for some people, they are not usually common side effects.
What class of drug is agomelatine?
Agomelatine belongs to a class of antidepressants known as melatonergic antidepressants. It works differently from SSRIs and SNRIs by acting on melatonin and serotonin receptors, which may help improve sleep patterns as well as mood.

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Lectures complémentaires et références
- Manufacturer's PIL, Valdoxan® 25 mg tablets; Servier Laboratories Limited, The electronic Medicines Compendium. Dated August 2023.
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Historique de l'article
Les informations sur cette page sont rédigées et examinées par des cliniciens qualifiés.
Prochaine révision prévue : 14 avr. 2028
14 avr. 2025 | Dernière version

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