Azathioprine

About azathioprine

Azathioprine is an immunosuppressant, which simply means that it suppresses your immune, or defence, system. It is used to help prevent rejection following organ transplant operations and also to treat a variety of long-term (chronic) inflammatory and autoimmune conditions, such as polyarthrite rhumatoïde, lupus érythémateux systémique, and maladie de Crohn.

Following organ transplant operations, it is natural for your body to try to reject the new tissue as it regards it as 'foreign'. By suppressing your defence system, azathioprine helps to prevent your body from fighting the new organ.

In chronic inflammatory and autoimmune conditions your immune system attacks part of your own body as if it were foreign. Azathioprine reduces inflammation and the symptoms it causes because it suppresses your immune system.

Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking azathioprine it is important that your doctor or pharmacist knows:

• Si vous êtes enceinte, essayez d'avoir un bébé ou allaitez.

• Si vous avez des problèmes de foie ou de reins.

• If you have any infection.

• If you have ever had chickenpox or shingles.

• If you have been told you have a rare, inherited metabolic disorder called Lesch-Nyhan syndrome or you have a lack of an enzyme called TPMT.

• Si vous prenez ou utilisez d'autres médicaments. Cela inclut tous les médicaments que vous prenez et qui sont disponibles à l'achat sans ordonnance, ainsi que les médicaments à base de plantes et complémentaires.

• If you have ever had an allergic reaction to a medicine. It is particularly important that you tell your doctor if you are allergic to a medicine called mercaptopurine.

• Before you start this treatment, read the manufacturer's printed information leaflet from inside your pack. The leaflet will give you more information about azathioprine, how to take it, and a full list of side-effects which you may experience from taking it.

• Your doctor will prescribe a dose for you which is tailored to your weight and the reason why you are taking it. Make sure you take the tablets exactly as your doctor has told you - your dose will be on the label of the pack to remind you.

• Take the tablets after eating a meal or with a snack. This will help to stop any feelings of queasiness or nausea. Drink plenty of water as you take the tablets.

• Do not drink milk or eat dairy products (such as yoghurt) at the same time as taking your azathioprine dose. Dairy products contain an enzyme which can break down azathioprine making your treatment less effective.

• Try to take your doses at the same time of day each day, as this will help you to remember to take them. If you forget to take a dose at the usual time, take one as soon as you remember, but do not take two doses together to make up for a missed dose.

• Your doctor will tell you how long your treatment is expected to continue. Keep taking azathioprine until your doctor tells you otherwise.

• Try to keep your regular appointments with your doctor. This is so your doctor can check on your progress. Your doctor will want you to have regular blood tests during this treatment, to monitor for unwanted side-effects.

• Ce médicament réduit votre protection naturelle contre les infections. Il est important de vous protéger contre les maladies graves en recevant les vaccinations que votre médecin vous propose. Si vous vivez avec d'autres personnes, elles peuvent également vous aider à vous protéger en recevant leurs propres vaccinations.

• Certains vaccins peuvent ne pas convenir aux personnes ayant un système immunitaire affaibli. Informez toujours la personne qui vous vaccine que vous prenez ce médicament.

• It is important to try to avoid anyone who has chickenpox or shingles. Tell your doctor if you come into contact with anyone with these infections.

• Your doctor will have discussed with you the possibility of a slightly increased risk of cancer (particularly skin cancer) associated with immunosuppressants like azathioprine. Do not use sunbeds, and avoid strong sunlight or use a sun cream with a high sun protection factor (SPF of at least 15).

• You should avoid becoming pregnant while you or your partner are taking azathioprine. Make sure you have discussed with your doctor which types of contraception are suitable for you and your partner.

• If you are having an operation or any dental treatment, tell the person carrying out the treatment that you are taking azathioprine.

• Si vous achetez des médicaments, vérifiez avec votre médecin ou un pharmacien qu'ils sont compatibles avec vos autres médicaments.

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with azathioprine. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following side-effects continue or become troublesome.

If you experience any other symptoms which you think may be due to this medicine, speak with your doctor or pharmacist for advice.

• Gardez tous les médicaments hors de la portée et de la vue des enfants.

• Conserver dans un endroit frais et sec, à l'abri de la chaleur et de la lumière directes.