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Dantrolène pour spasmes musculaires chroniques

Dantrium

When you first start taking dantrolene, your doctor will give you a small dose (one capsule a day). Your dose will then be increased slowly at weekly intervals.

Dantrolene can make you feel sleepy or dizzy. It can slow your reactions, so please take care if you are using tools or machines, or if you drive.

Dantrolene can cause liver damage in a few people. Signs of this are loss of appetite, tiredness, itching, jaundice, and sickness. Let your doctor know straightaway if you develop any of these, so that it can be investigated.

En un coup d'œil

  • Dantrolene is a muscle relaxant used to reduce muscle spasms and spasticity.

  • It is often prescribed for conditions like multiple sclerosis, motor neurone disease, or after head/back injuries.

  • Your doctor will start with a low dose and gradually increase it.

  • Common side-effects include feeling dizzy, sleepy, or experiencing diarrhoea.

  • Do not drink alcohol while taking dantrolene, as it can worsen side-effects.

  • Signs of liver problems, like yellowing skin or dark urine, require urgent medical attention.

About dantrolene

Type de médicament

A muscle relaxant

Utilisé pour

Muscle spasms and spasticity

Aussi appelé

Dantrium®

Disponible sous forme de

Capsules

Dantrolene belongs to a group of medicines called muscle relaxants. Muscle relaxants are medicines that are used to prevent or reduce muscle spasms and spasticity. Muscle spasms occur when there is an uncontrolled (involuntary) contraction of a group of muscles. This often causes pain and discomfort. Spasticity occurs when the muscles contract tightly and then become stiff and harder to use.

Dantrolene is used to relieve muscle spasms and spasticity which result from long-term conditions affecting the nervous system, such as sclérose en plaques, maladie du motoneurone ou la paralysie cérébrale, or following long-term injuries to the head or back. It works by causing the muscles to relax and this reduces pain and discomfort.

Before taking dantrolene

Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking dantrolene it is important that your doctor knows:

  • If you have any problems with the way your liver works, or if you have a heart condition, or if you have any difficulties with your breathing.

  • Si vous êtes enceinte ou si vous allaitez.

  • Si vous prenez ou utilisez d'autres médicaments. Cela inclut tous les médicaments que vous prenez et qui sont disponibles à l'achat sans ordonnance, ainsi que les médicaments à base de plantes et complémentaires.

  • Si vous avez déjà eu une réaction allergique à un médicament.

How to take dantrolene

  • Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about dantrolene and will provide you with a full list of the side-effects which you may experience from taking it.

  • When starting the treatment, your doctor will give you a small dose (usually one 25 mg capsule daily) and will then gradually increase your dose at weekly intervals. This allows your doctor to make sure that you have the dose that helps your condition but avoids any unwanted symptoms.

  • Swallow the capsule with a drink of water. You can take dantrolene either before or after a meal.

  • Continue to take dantrolene exactly as your doctor tells you to. Your dose will be printed on the label of the pack to remind you about what your doctor said to you. Once you are established on a regular dose of dantrolene, try to take your doses at the same times of day each day, as this will help you to remember to take them.

  • If you do forget to take a dose, take it when you remember unless your next dose is about due. If it is nearly time for your next dose then take the next dose when it is due but leave out the forgotten dose. Do not take two doses together to make up for a missed dose.

Tirer le meilleur parti de votre traitement

  • Try to keep your regular appointments with your doctor. This is so your doctor can check on your progress, as it may take a few weeks before you begin to feel the benefit from dantrolene.

  • If after six weeks or so you don't feel you are improving, please speak with your doctor about this, as your treatment could need reviewing.

  • Dantrolene can cause drowsiness and may affect your reactions. Be careful this does not put you at risk if you are using any tools or machines, or if you drive.

  • It is recommended that you do not drink alcohol while you are on dantrolene. This is because the risk of side-effects, such as feeling sleepy and dizzy, is increased.

  • Treatment with dantrolene is usually long-term unless you experience an adverse event. Continue to take the capsules unless your doctor tells you otherwise. If your muscle spasms increase or if you have difficulty doing things because you feel your muscles have become weak, let your doctor know about this, as your dose may need adjusting.

  • Si vous subissez une opération ou un traitement dentaire, informez la personne qui effectue le traitement des médicaments que vous prenez.

Can dantrolene cause problems?

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with dantrolene. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine but speak with your doctor or pharmacist if any of the following continue or become troublesome.

Common dantrolene side-effects (these affect fewer than 1 in 10 people)

Que puis-je faire si je ressens cela ?

Feeling dizzy, sleepy, or very tired

Si cela se produit, ne conduisez pas et n'utilisez pas d'outils ou de machines. Ne buvez pas d'alcool

Diarrhée

Drink plenty of water to replace the lost fluids. If the diarrhoea is severe, speak with your doctor about this as you may need to stop taking dantrolene for a while

Sensation de malaise (nausée) ou vomissements, douleur au ventre (abdominale)

Mangez des repas simples - évitez les aliments riches ou épicés

Maux de tête

Buvez beaucoup d'eau et demandez à votre pharmacien de vous recommander un antidouleur approprié. Si les maux de tête persistent, informez votre médecin

Loss of appetite, skin rash or acne, speech or sight difficulties, high temperature (fever), chills, difficulties breathing, fits, and inflammation of the lining around the heart (sometimes with fluid in the lungs)

If you are concerned about any of these, speak with your doctor for advice

Important: your doctor will discuss with you the possibility that your medicine could cause damage to your liver. If you experience any of the following you should let your doctor know straightaway so that it can be investigated:

  • Perte d'appétit

  • Extreme tiredness

  • Dark urine

  • Démangeaisons

  • Yellowing of your skin or the whites of your eyes (jaundice)

  • Constantly feeling sick (nausea) or being sick (vomiting)

  • Pain in your tummy (abdomen)

These are signs that your liver could be being damaged and your doctor will want you to have a blood test to check for this.

Si vous ressentez d'autres symptômes que vous pensez être dus à ce médicament, discutez-en avec votre médecin ou votre pharmacien.

How to store dantrolene

  • Gardez tous les médicaments hors de la portée et de la vue des enfants.

  • Conserver dans un endroit frais et sec, à l'abri de la chaleur et de la lumière directes.

Informations importantes sur tous les médicaments

Informations importantes sur tous les médicaments

Ne prenez jamais plus que la dose prescrite. Si vous soupçonnez que vous ou quelqu'un d'autre avez pris une surdose de ce médicament, rendez-vous au service des urgences de votre hôpital local. Emportez le contenant avec vous, même s'il est vide.

Ce médicament est pour vous. Ne le donnez pas à d'autres personnes même si leur état semble être le même que le vôtre.

Si vous achetez des médicaments, vérifiez avec un pharmacien qu'ils sont compatibles avec vos autres médicaments.

Ne gardez pas de médicaments périmés ou indésirables. Apportez-les à votre pharmacie locale qui s'en débarrassera pour vous.

Si vous avez des questions concernant ce médicament, demandez à votre pharmacien.

Signaler les effets secondaires d'un médicament ou d'un vaccin

Si vous ressentez des effets secondaires, vous pouvez les signaler en ligne via le Site web de Yellow Card.

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Questions fréquemment posées

What happens if I miss a dose of dantrolene?

If you forget to take a dose, take it as soon as you remember. However, if it's nearly time for your next dose, skip the one you missed and just take your next dose as scheduled. Do not take a double dose to make up for a forgotten one.

How long will I need to take dantrolene?

Treatment with dantrolene is usually considered long-term, unless you experience an adverse event. You should continue to take the capsules as prescribed by your doctor. Do not stop taking them unless your doctor advises you to do so.

What should I do if the dantrolene doesn't seem to be working after a few weeks?

It can take a few weeks for dantrolene to start showing benefits. If you haven't noticed any improvement after about six weeks, you should speak with your doctor. They may need to review your treatment plan.

Are there any specific symptoms I should watch out for that might indicate a serious problem while taking dantrolene?

Yes. You should immediately inform your doctor if you experience loss of appetite, extreme tiredness, dark urine, itching, yellowing of your skin or eyes (jaundice), constantly feeling sick or being sick, or pain in your tummy. These could be signs of liver damage, and your doctor will likely want to perform a blood test to investigate.

Can I take other medicines, including over-the-counter remedies or herbal supplements, while on dantrolene?

It's important to tell your doctor about all medicines you are taking, including those available without a prescription, as well as any herbal or complementary medicines. This allows your doctor to ensure that they are safe to take alongside dantrolene and avoid any potential interactions.

What should I do if my muscle spasms get worse or my muscles feel weak while taking dantrolene?

If you notice that your muscle spasms are increasing or if you find yourself struggling to do things because your muscles feel weak, you should inform your doctor. Your dose of dantrolene may need to be adjusted to better manage your condition.

Lectures complémentaires et références

À propos de l'auteurVoir la biographie complète

Image de l'auteur

Michael Stewart, MRPharmS

Responsable de l'examen des notices de médicaments – Contractuel, Pharmacien

BPharm (Hons), MRPharmS

Michael est un pharmacien communautaire exerçant dans les Midlands et le South Yorkshire avec plus de 20 ans d'expérience dans le conseil sur les médicaments et les conditions médicales. Il possède une solide expérience en formation dans le domaine de la santé, ayant produit et dispensé des cours de formation pour les équipes de pharmacie et le personnel des établissements de soins résidentiels, y compris les infirmières. Il a également contribué aux comités consultatifs de pharmacie pour la gestion des affections de faible gravité dans la communauté.

À propos du critique

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Sid Dajani

Sultan Dajani a obtenu son diplôme à la London School of Pharmacy en 1994 et est devenu le plus jeune membre élu du conseil de la Royal Pharmaceutical Society depuis sa fondation en 1842.

Historique de l'article

Les informations sur cette page sont rédigées et examinées par des cliniciens qualifiés.

  • Prochaine révision prévue : 23 juin 2027
  • 21 juin 2024 | Dernière version

    Dernière mise à jour par

    Michael Stewart, MRPharmS

    Revu par

    Sid Dajani
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