Dantrolène pour spasmes musculaires chroniques
Dantrium
Revu par Sid DajaniDernière mise à jour par Michael Stewart, MRPharmSDernière mise à jour 21 juin 2024
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When you first start taking dantrolene, your doctor will give you a small dose (one capsule a day). Your dose will then be increased slowly at weekly intervals.
Dantrolene can make you feel sleepy or dizzy. It can slow your reactions, so please take care if you are using tools or machines, or if you drive.
Dantrolene can cause liver damage in a few people. Signs of this are loss of appetite, tiredness, itching, jaundice, and sickness. Let your doctor know straightaway if you develop any of these, so that it can be investigated.
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About dantrolene
Type de médicament | A muscle relaxant |
Utilisé pour | Muscle spasms and spasticity |
Aussi appelé | Dantrium® |
Disponible sous forme de | Capsules |
Dantrolene belongs to a group of medicines called muscle relaxants. Muscle relaxants are medicines that are used to prevent or reduce muscle spasms and spasticity. Muscle spasms occur when there is an uncontrolled (involuntary) contraction of a group of muscles. This often causes pain and discomfort. Spasticity occurs when the muscles contract tightly and then become stiff and harder to use.
Dantrolene is used to relieve muscle spasms and spasticity which result from long-term conditions affecting the nervous system, such as sclérose en plaques, maladie du motoneurone ou la paralysie cérébrale, or following long-term injuries to the head or back. It works by causing the muscles to relax and this reduces pain and discomfort.
Before taking dantrolene
Retour au sommaireSome medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking dantrolene it is important that your doctor knows:
If you have any problems with the way your liver works, or if you have a heart condition, or if you have any difficulties with your breathing.
Si vous êtes enceinte ou si vous allaitez.
Si vous prenez ou utilisez d'autres médicaments. Cela inclut tous les médicaments que vous prenez et qui sont disponibles à l'achat sans ordonnance, ainsi que les médicaments à base de plantes et complémentaires.
Si vous avez déjà eu une réaction allergique à un médicament.
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How to take dantrolene
Retour au sommaireBefore you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about dantrolene and will provide you with a full list of the side-effects which you may experience from taking it.
When starting the treatment, your doctor will give you a small dose (usually one 25 mg capsule daily) and will then gradually increase your dose at weekly intervals. This allows your doctor to make sure that you have the dose that helps your condition but avoids any unwanted symptoms.
Swallow the capsule with a drink of water. You can take dantrolene either before or after a meal.
Continue to take dantrolene exactly as your doctor tells you to. Your dose will be printed on the label of the pack to remind you about what your doctor said to you. Once you are established on a regular dose of dantrolene, try to take your doses at the same times of day each day, as this will help you to remember to take them.
If you do forget to take a dose, take it when you remember unless your next dose is about due. If it is nearly time for your next dose then take the next dose when it is due but leave out the forgotten dose. Do not take two doses together to make up for a missed dose.
Tirer le meilleur parti de votre traitement
Retour au sommaireTry to keep your regular appointments with your doctor. This is so your doctor can check on your progress, as it may take a few weeks before you begin to feel the benefit from dantrolene.
If after six weeks or so you don't feel you are improving, please speak with your doctor about this, as your treatment could need reviewing.
Dantrolene can cause drowsiness and may affect your reactions. Be careful this does not put you at risk if you are using any tools or machines, or if you drive.
It is recommended that you do not drink alcohol while you are on dantrolene. This is because the risk of side-effects, such as feeling sleepy and dizzy, is increased.
Treatment with dantrolene is usually long-term unless you experience an adverse event. Continue to take the capsules unless your doctor tells you otherwise. If your muscle spasms increase or if you have difficulty doing things because you feel your muscles have become weak, let your doctor know about this, as your dose may need adjusting.
Si vous subissez une opération ou un traitement dentaire, informez la personne qui effectue le traitement des médicaments que vous prenez.
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Can dantrolene cause problems?
Retour au sommaireAlong with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with dantrolene. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine but speak with your doctor or pharmacist if any of the following continue or become troublesome.
Common dantrolene side-effects (these affect fewer than 1 in 10 people) | Que puis-je faire si je ressens cela ? |
Feeling dizzy, sleepy, or very tired | Si cela se produit, ne conduisez pas et n'utilisez pas d'outils ou de machines. Ne buvez pas d'alcool |
Diarrhée | Drink plenty of water to replace the lost fluids. If the diarrhoea is severe, speak with your doctor about this as you may need to stop taking dantrolene for a while |
Sensation de malaise (nausée) ou vomissements, douleur au ventre (abdominale) | Mangez des repas simples - évitez les aliments riches ou épicés |
Maux de tête | Buvez beaucoup d'eau et demandez à votre pharmacien de vous recommander un antidouleur approprié. Si les maux de tête persistent, informez votre médecin |
Loss of appetite, skin rash or acne, speech or sight difficulties, high temperature (fever), chills, difficulties breathing, fits, and inflammation of the lining around the heart (sometimes with fluid in the lungs) | If you are concerned about any of these, speak with your doctor for advice |
Important: your doctor will discuss with you the possibility that your medicine could cause damage to your liver. If you experience any of the following you should let your doctor know straightaway so that it can be investigated:
Perte d'appétit
Extreme tiredness
Dark urine
Démangeaisons
Yellowing of your skin or the whites of your eyes (jaundice)
Constantly feeling sick (nausea) or being sick (vomiting)
Pain in your tummy (abdomen)
These are signs that your liver could be being damaged and your doctor will want you to have a blood test to check for this.
If you experience any other symptoms which you think may be due to this medicine, discuss them with your doctor or pharmacist.
How to store dantrolene
Retour au sommaireGardez tous les médicaments hors de la portée et de la vue des enfants.
Store in a cool, dry place, away from direct heat and light.
Informations importantes sur tous les médicaments
Retour au sommaireInformations importantes sur tous les médicaments
Ne prenez jamais plus que la dose prescrite. Si vous soupçonnez que vous ou quelqu'un d'autre avez pris une surdose de ce médicament, rendez-vous au service des urgences de votre hôpital local. Emportez le contenant avec vous, même s'il est vide.
Ce médicament est pour vous. Ne le donnez pas à d'autres personnes même si leur état semble être le même que le vôtre.
Si vous achetez des médicaments, vérifiez avec un pharmacien qu'ils sont compatibles avec vos autres médicaments.
Ne gardez pas de médicaments périmés ou indésirables. Apportez-les à votre pharmacie locale qui s'en débarrassera pour vous.
Si vous avez des questions concernant ce médicament, demandez à votre pharmacien.
Signaler les effets secondaires d'un médicament ou d'un vaccin
Si vous ressentez des effets secondaires, vous pouvez les signaler en ligne via le site web Yellow Card.

Vous n'êtes pas sûr de mélanger des médicaments ?
Vérifiez les interactions possibles entre les médicaments, les compléments et les aliments avant de les prendre ensemble.
Lectures complémentaires et références
- Manufacturer's PIL, Dantrium® 25 mg and 100 mg Capsules; Norgine Limited, The electronic Medicines Compendium. Dated August 2023.
- Médicaments Complets BNF 89e Édition; Association Médicale Britannique et Société Royale Pharmaceutique de Grande-Bretagne, Londres.
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Historique de l'article
Les informations sur cette page sont rédigées et examinées par des cliniciens qualifiés.
Prochaine révision prévue : 23 juin 2027
21 juin 2024 | Dernière version

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