Comprimés et capsules de doxycycline
Periostat, Vibramycin-D
Revu par Dr Colin Tidy, MRCGPDernière mise à jour par Michael Stewart, MRPharmSDernière mise à jour 5 mai 2025
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Take doxycycline with plenty of water. Stand or sit up to take your doses - this will stop the capsules/tablets from causing any irritation to your throat.
Make sure you continue to take the medicine until you finish the full course prescribed.
Do not take indigestion remedies, or supplements containing iron, magnesium, or zinc at the same time as doxycycline as they stop it from working properly.
The most common side effects of doxycycline are diarrhoea, upset stomach, stomach pain, and headache.
En un coup d'œil
Doxycycline is an antibiotic used to treat bacterial infections and prevent malaria.
Common side effects include upset stomach, indigestion, tummy pain, diarrhoea, and headache.
Take capsules with a large glass of water while sitting or standing, not right before bed.
Avoid antacids and supplements with iron, magnesium, or zinc within 2 hours of taking doxycycline.
Doxycycline can make your skin sensitive to sunlight, so use high-factor sun cream.
Do not take doxycycline if you are pregnant or breastfeeding.
Seek medical attention for severe side effects like allergic reactions or vision changes.
About doxycycline
Type de médicament | A tetracycline antibiotic |
Utilisé pour | Bacterial infections; to prevent malaria. |
Aussi appelé (Royaume-Uni) | Efracea®, Periostat®, Vibramycin-D® |
Aussi appelé (États-Unis) | Acticlate®, Doryx®, Mondoxyne®, Monodox®, Okebo®, Oracea®, Targadox®, Vibramycin® |
Disponible sous forme de | Capsules, modified-release capsules, dispersible tablets; oral liquid medicine (USA) |
What is doxycycline used for?
Doxycycline is a type of antibiotic that is used to treat a number of different types of infection, including chest infections, some skin conditions, les infections sexuellement transmissibles, and infections in or around the mouth.
Doxycycline is also used to prevent people from getting paludisme when they travel to countries where malaria occurs.
Although doxycycline can only be obtained on a prescription from a doctor, it is not prescribable on the NHS to prevent malaria. This means that you will be given a private (non-NHS) prescription and you will be asked to pay the full price for the tablets/capsules if you are taking it for this reason.
Doxycycline side effects
Common side effects of doxycycline are:
Maux d'estomac.
Indigestion.
Douleur au ventre (abdominale).
Diarrhée.
Maux de tête.
Douleurs et courbatures.
Yeast infection (thrush).
Bouche sèche.
Anxiété.
Increased sweating.
You will find a full list in the manufacturer's information leaflet supplied with your medicine. Speak with your doctor or pharmacist if any of these side effects continue or become troublesome.
How to manage doxycycline side effects
Doxycycline side effects | Que puis-je faire si je ressens cela ? |
Stomach upset, indigestion, tummy pain | Stick to simple foods - avoid fatty or spicy meals. Take your doses after a meal or with a snack |
Diarrhée | Drink plenty of water to replace lost fluids. If this continues or is severe, speak with a doctor |
Maux de tête, autres douleurs et souffrances | Drink plenty of water and ask a pharmacist to recommend a suitable painkiller. If the aches continue, let your doctor know |
A yeast infection which causes redness and itchiness in the mouth or vagina | Speak with a doctor or pharmacist for advice |
Dry mouth, throat irritation | Remember to take your doses with a large glass of water while you are standing or sitting upright |
Feeling anxious, increased sweating | If troublesome, speak with a doctor |
Important: doxycycline can occasionally cause allergic reactions, such as a skin rash, swollen lips or tongue and difficulty breathing. Seek medical attention as soon as possible if this happens to you.
Remember that doxycycline may make your skin more sensitive to sunlight than usual, causing rash-like symptoms. Use a sun cream with a high sun protection factor on bright days and use a moisturiser to soothe irritated skin.
In rare cases, treatment with tetracycline antibiotics can cause an increase in blood pressure inside the skull. This can cause symptoms such as headache, being sick (vomiting) and vision problems such as blurred or double vision or loss of vision. If this happens to you, seek medical attention and do not take any more of this medicine.
If you experience any other symptoms which you think may be due to the medicine, discuss them with your doctor or pharmacist who will be able to advise you further.
Who should not take doxycycline?
Some medicines are not suitable for people with certain conditions. Before starting doxycycline it is important that your doctor or pharmacist knows:
Si vous êtes enceinte, essayez d'avoir un bébé ou allaitez.
Si vous avez des problèmes avec le fonctionnement de votre foie, ou si vous avez des problèmes avec le fonctionnement de vos reins.
Si vous avez une affection inflammatoire appelée lupus érythémateux systémique (également appelé lupus, ou LES).
Si vous avez une affection provoquant une faiblesse musculaire, appelée myasthénie grave.
Si vous prenez d'autres médicaments. Cela inclut tous les médicaments disponibles à l'achat sans ordonnance, ainsi que les médicaments à base de plantes et les médecines complémentaires.
Si vous avez déjà eu une réaction allergique à un médicament.
How to take doxycycline
Read the leaflet in the pack before starting doxycycline. It explains how to take it and lists possible side effects.
Take doxycycline exactly as your doctor tells you. It is usually one dose a day however some people will be prescribed two. For mouth ulcers you may be asked to take four doses a day.
If taking capsules, you must swallow these whole with a glass of water during mealtime. Sit or stand while taking it, and do not take right before bed to avoid throat irritation.
If you have been given dispersible tablets (Vibramycin-D®), you should stir these into a small glass of water to take them. Rinse the solution around your mouth for 2-3 minutes, and then spit it out.
If you forget to take a dose, take it as soon as you remember. Try to take the correct number of doses each day but do not take two doses at the same time to make up for a missed dose.
Depending on what you are being treated for, your course of treatment could last from a week, to several months. Keep taking doxycycline until the course is finished unless you are told to stop sooner by a doctor.
Tirer le meilleur parti de votre traitement
Avoid taking antacids or supplements with iron, magnesium, or zinc within 2 hours before or after doxycycline, as they can make it less effective.
Doxycycline may cause your skin to become more sensitive to sunlight than usual. Avoid strong sunlight and do not use sunbeds. Use a sun cream with a high sun protection factor on bright days, even when it is cloudy.
This antibiotic may stop the oral vaccin oral contre la typhoïde from working. If you are having any vaccinations, make sure the person treating you knows that you are taking this medicine.
You will be prescribed a brand of doxycycline that is appropriate for your need, as not all brands are suitable for all of these indications.
Information for protection against malaria
If you are taking doxycycline to protect against malaria, you must start taking it 1-2 days before you travel. This is to ensure there is sufficient medicine in your bloodstream to give you the required protection. You should continue to take it throughout your stay and for a further four weeks after you have left the area.
Si vous vous sentez malade ou développez une forte température (fièvre) ou des symptômes grippaux pendant votre voyage ou dans l'année suivant votre retour (surtout si c'est dans les trois mois), vous devriez consulter votre médecin immédiatement. C'est important, même si vous avez pris vos comprimés antipaludiques correctement.
Doxycycline will help reduce the risk of you getting malaria, but it is also important that you take the following precautions against being bitten by mosquitoes:
Couvrez les zones découvertes de vos bras et jambes avec des vêtements amples à manches longues, des pantalons longs et des chaussettes. Cela est particulièrement important si vous êtes à l'extérieur après le coucher du soleil, car c'est à ce moment que les moustiques se nourrissent.
Utilisez un spray répulsif efficace contre les insectes sur vos vêtements et sur toute zone de votre peau qui est exposée. Si vous utilisez également un écran solaire, appliquez d'abord l'écran solaire, puis le répulsif.
Vaporisez la pièce avec un insecticide chaque soir, quelques heures avant d'aller vous coucher. Vérifiez vos zones de couchage pour les moustiques - portez une attention particulière aux meubles et aux zones sous votre lit où les insectes peuvent se cacher.
Si vous dormez dans une pièce non protégée, utilisez une moustiquaire imprégnée d'insecticide.
How to store doxycycline
Gardez tous les médicaments hors de la portée et de la vue des enfants.
Conserver dans un endroit frais et sec, à l'abri de la chaleur et de la lumière directes.
Informations importantes sur tous les médicaments
Informations importantes sur tous les médicaments
Ne prenez jamais plus que la dose prescrite. Si vous soupçonnez que vous ou quelqu'un d'autre avez pris une surdose de ce médicament, rendez-vous au service des urgences de votre hôpital local. Emportez le contenant avec vous, même s'il est vide.
Si vous subissez une opération ou un traitement dentaire, informez la personne qui effectue le traitement des médicaments que vous prenez.
Ce médicament est pour vous. Ne le donnez jamais à d'autres personnes, même si leur état semble être le même que le vôtre.
Ne gardez pas de médicaments périmés ou indésirables. Apportez-les à votre pharmacie locale qui s'en débarrassera pour vous.
Si vous avez des questions concernant ce médicament, demandez à votre pharmacien.
Signaler les effets secondaires d'un médicament ou d'un vaccin
Si vous ressentez des effets secondaires, vous pouvez les signaler en ligne via le Site web de Yellow Card.
Questions fréquemment posées
How long does doxycycline take to work?
Doxycycline usually starts working within 24 to 48 hours. Most people notice improvement in their symptoms after 2 to 3 days, but you should keep taking the medicine for the full course prescribed, even if you feel better.
Can you drink alcohol with doxycycline?
Yes, you can drink alcohol in moderation while taking doxycycline as alcohol does not stop doxycycline from working. However, drinking too much can increase side effects such as upset stomach, dizziness, or dehydration. For best results limit your alcohol intake until you finish your course.
Is doxycycline safe to take during pregnancy?
No, doxycycline is generally not safe to take during pregnancy. It can affect the development of a baby’s bones and teeth, especially in the second and third trimesters. Always let your doctor know if you are pregnant or planning to become pregnant so you can be prescribed a safer antibiotic.
Does doxycycline make you tired?
Doxycycline can make some people feel tired but it is not a common side effect. If tiredness is severe or doesn't go away, speak to your doctor.
How long does doxycycline stay in your system?
Doxycycline has a half-life of about 18-22 hours, which means it takes roughly 1-2 days for most of it to leave your system after your last dose. However, trace amounts can stay for a few days longer. It is usually fully cleared within 5 days.

Vous n'êtes pas sûr de mélanger des médicaments ?
Vérifiez les interactions possibles entre les médicaments, les compléments et les aliments avant de les prendre ensemble.
Questions fréquemment posées
What types of infections can doxycycline treat?
Doxycycline is an antibiotic used for various infections, including those affecting the chest, some skin conditions, sexually transmitted infections, and infections in or around the mouth. It is also used to prevent malaria.
Are there any specific foods or drinks I should avoid while taking doxycycline?
You should avoid taking antacids or supplements containing iron, magnesium, or zinc within two hours before or after taking doxycycline, as they can reduce its effectiveness. While you can drink alcohol in moderation, it's best to limit it as it can worsen side effects like an upset stomach.
How should I take doxycycline to avoid irritating my throat?
If you are taking capsules, swallow them whole with a glass of water during mealtime. It's important to sit or stand upright when taking them and avoid lying down right before bed to prevent throat irritation. If you have dispersible tablets, stir them into a small glass of water, rinse for a few minutes, and then spit out the solution.
Can doxycycline make my skin more susceptible to sunburn?
Yes, doxycycline can increase your skin's sensitivity to sunlight. You should avoid strong sunlight and sunbeds. When outdoors, even on cloudy days, use a sun cream with a high sun protection factor to protect your skin.
What should I do if I forget to take a dose of doxycycline?
If you forget a dose, take it as soon as you remember. However, do not take two doses at the same time to make up for the missed one. The aim is to take the correct number of doses each day.
What should I do if I experience a severe allergic reaction to doxycycline?
If you experience symptoms of an allergic reaction, such as a skin rash, swollen lips or tongue, or difficulty breathing, you should seek medical attention as soon as possible.
How long do I need to take doxycycline for malaria prevention?
For malaria prevention, you need to start taking doxycycline one to two days before you travel. You should continue taking it throughout your stay in the malaria-prone area and for an additional four weeks after you return home.
Lectures complémentaires et références
- Manufacturer's PIL, Doxycycline 50 mg and 100 mg capsules; Sovereign Medical, The electronic Medicines Compendium. Dated March 2024.
- Manufacturer's PIL, Vibramycin-D Dispersible Tablets 100 mg; Pfizer Ltd, The electronic Medicines Compendium. Dated December 2023.
À propos de l'auteurVoir la biographie complète

Michael Stewart, MRPharmS
Responsable de l'examen des notices de médicaments – Contractuel, Pharmacien
BPharm (Hons), MRPharmS
Michael est un pharmacien communautaire exerçant dans les Midlands et le South Yorkshire avec plus de 20 ans d'expérience dans le conseil sur les médicaments et les conditions médicales. Il possède une solide expérience en formation dans le domaine de la santé, ayant produit et dispensé des cours de formation pour les équipes de pharmacie et le personnel des établissements de soins résidentiels, y compris les infirmières. Il a également contribué aux comités consultatifs de pharmacie pour la gestion des affections de faible gravité dans la communauté.
À propos du critiqueVoir la biographie complète

Dr Colin Tidy, MRCGP
Médecin généraliste, Auteur médical
MBBS, MRCGP, MRCP (Paediatrics), DCH
Le Dr Colin Tidy est un médecin du NHS, basé dans l'Oxfordshire.
Historique de l'article
Les informations sur cette page sont rédigées et examinées par des cliniciens qualifiés.
Article également disponible en Anglais, Allemand, Espagnol, Français, Italien, Portugais, Hindi, Hébreu, Arabe, and Suédois.
Prochaine révision prévue : 5 mai 2028
5 mai 2025 | Dernière version

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