Pyrazinamide for tuberculosis

About pyrazinamide

Pyrazinamide is used to treat la tuberculose (TB). TB is a bacterial infection which mostly affects the lungs, but which can affect any part of your body. It is treatable with a course of medicines which usually lasts for six months in total. You will need to take several medicines to treat TB - pyrazinamide is just one of the medicines prescribed. You will be prescribed pyrazinamide to take during the first two months of your treatment.

Pyrazinamide is usually prescribed as a tablet which contains a combination of three or four medicines to treat TB. The brand names of these are Rifater®, Rimstar® and Voractiv®. Taking a combination brand helps to reduce the total number of tablets you need to take each day. You may be prescribed one of these combination brands, or alternatively you may be prescribed a tablet containing only pyrazinamide (brand name Zinamide®). This brand must be taken alongside other medicines for TB.

Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking pyrazinamide it is important that your doctor knows:

• Si vous êtes enceinte ou si vous allaitez.

• If you have any problems with the way your kidneys work, or the way your liver works.

• If you have gout or diabetes.

• If you drink a lot of alcohol.

• Si vous avez la porphyrie, une maladie sanguine héréditaire rare.

• Si vous prenez d'autres médicaments. Cela inclut tous les médicaments que vous prenez et qui sont disponibles à l'achat sans ordonnance, ainsi que les médicaments à base de plantes et les médecines complémentaires.

• Si vous avez déjà eu une réaction allergique à un médicament.

• Before you start treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about the brand of tablets you have been given and will provide you with a full list of the side-effects which you may experience.

• It is important that you take the medicines to treat TB exactly as your doctor tells you to. You will normally be asked to take pyrazinamide every day. Your doctor will explain to you how many tablets to take each day, and this information will be printed on the label of the pack of tablets to remind you. If when you collect your supply of tablets you are unclear about how to take them, ask your pharmacist to explain. If you are undergoing directly observed therapy (DOT), you will be asked to take pyrazinamide three times a week while you are being supervised by a healthcare observer.

• It is usually recommended that you take pyrazinamide at the same time of day as your other antituberculosis medicines.

• It is important that you keep your regular appointments with your doctor. This is so your doctor can check on your progress. Your doctor may want you to have blood tests from time to time during treatment to make sure that your liver stays healthy.

• Continue to take the tablets regularly unless your doctor tells you to stop. This is because it is important for you to complete the treatment course so that the infection does not come back. If for any reason you stop taking the tablets (such as if you think you may be developing side-effects - see also below) then you must let your doctor know about it immédiatement.

• Pyrazinamide may stop the oral typhoid vaccine from working. If you are having any vaccinations, make sure the person treating you knows that you are taking this medicine.

• Si vous subissez une opération ou un traitement dentaire, informez la personne qui effectue le traitement des médicaments que vous prenez.

• If you buy any medicines, check with a pharmacist that they are suitable for you to take with your other medicines.

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains the most common ones associated with pyrazinamide - please contact your doctor straightaway if you experience these symptoms. You will find a list of other side-effects associated with pyrazinamide in the manufacturer's information leaflet supplied with your medicine.

Si vous ressentez d'autres symptômes que vous pensez être dus au médicament, parlez-en à votre médecin ou à votre pharmacien pour obtenir des conseils supplémentaires.

• Gardez tous les médicaments hors de la portée et de la vue des enfants.

• Conserver dans un endroit frais et sec, à l'abri de la chaleur et de la lumière directes.