Maraviroc tablets for HIV

About maraviroc

Maraviroc is an antiretroviral medicine. It is used for infection par le virus de l'immunodéficience humaine (VIH). It slows the progress of HIV infection but it is not a cure. HIV destroys cells in the body, called CD4 T cells. These cells are a type of white blood cell and are important because they are involved in protecting your body from infection. If left untreated, the HIV infection weakens your immune system so that your body cannot defend itself against bacteria, viruses and other germs. Maraviroc is known as a CCR5 antagonist antiretroviral medicine. It works by blocking a receptor, called CCR5, which HIV uses to enter your CD4 T cells. By reducing the amount of virus getting into your cells, it helps to maintain the health of your immune system.

Maraviroc will be prescribed for you by a doctor who is a specialist. it is given alongside a number of other antiretroviral medicines, as part of a combination therapy. Taking three or more antiretroviral medicines at the same time is more effective than taking one alone. Taking a combination of different medicines also reduces the risk that the virus will become resistant to any individual medicine. It is vital to take them exactly as prescribed to maintain success and to help to prevent the virus from becoming resistant to the medicines. These medicines are usually taken for life.

Some medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. For these reasons, before you start taking maraviroc it is important that your doctor knows:

• Si vous êtes enceinte ou si vous allaitez.

• Si vous avez des problèmes avec le fonctionnement de votre foie, ou si vous avez des problèmes avec le fonctionnement de vos reins.

• If you have any problems with your heart or blood vessels.

• Si vous prenez d'autres médicaments. Cela inclut tous les médicaments disponibles à l'achat sans ordonnance, ainsi que les médicaments à base de plantes et les médecines complémentaires.

• If you have ever had an allergic reaction to a medicine, or if you are allergic to peanuts or soya.

• Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about maraviroc, and it will also provide you with a full list of the side-effects which you could experience from taking it.

• Take maraviroc exactly as your doctor tells you to. It is usual to take one 300 mg tablet twice daily, although your dose may be more or less than this depending upon which other medicines you are also taking.

• If you (or your child) have been supplied with oral liquid medicine, follow the instructions in the pack for measuring out the correct dose using the syringe and adapter provided.

• Your dose of maraviroc can be taken with or without food.

• Try to take your doses at the same times of day each day, as this will help you to remember to take maraviroc regularly.

• Si vous oubliez de prendre une dose, prenez-la dès que vous vous en souvenez (sauf s'il est presque l'heure de votre prochaine dose, auquel cas laissez tomber la dose oubliée). Ne prenez pas deux doses ensemble pour compenser une dose oubliée.
  

• Gardez vos rendez-vous réguliers avec votre médecin afin que vos progrès puissent être suivis. Vous devrez effectuer des analyses de sang régulières.

• It is important that you continue to take maraviroc and your other antiretroviral treatment regularly. This will help to prevent the HIV from becoming resistant to the medicines you are taking. Even if you miss only a small number of doses, the virus can become resistant to treatment.

• If you develop any infection soon after you start the treatment, let your doctor know. As a result of taking maraviroc, your immune system may start fighting an infection which was present before you started the treatment, but which you may not have been aware of.

• Follow carefully any advice your doctor gives to you about making some lifestyle changes to reduce any risk of damage to your heart and blood vessels. These can include stopping smoking, eating healthily and taking regular exercise.

• Although treatment with antiretroviral medicines can reduce the risk of you passing HIV to others through sexual contact, it does not stop it. It is important that you use condoms.

• It is not uncommon for people with HIV to feel low or even depressed, especially soon after the diagnosis has been made and treatment has been started. If you have any feelings of depression you should speak with your doctor straightaway.

• Certaines personnes qui ont pris des médicaments antirétroviraux (en particulier sur une longue période) ont développé une affection appelée ostéonécrose. Il s'agit d'une maladie osseuse où le tissu osseux meurt en raison d'une réduction de l'apport sanguin. Cela entraîne des douleurs articulaires et une raideur, et peut causer des difficultés de mouvement. Si vous remarquez l'un de ces symptômes, parlez-en à votre médecin.

• If you buy any medicines or herbal remedies 'over the counter', check with a pharmacist that they are suitable to take alongside maraviroc and your other medicines. This is because some medicines interfere with antiretrovirals and can stop them from working properly.

• Si vous subissez une opération ou un traitement dentaire, informez toujours la personne effectuant le traitement des médicaments que vous prenez.

• Treatment for HIV is usually lifelong. Continue to take maraviroc regularly, even if you feel well. This is to keep your immune system healthy.

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with maraviroc. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.

Important: occasionally, some people taking maraviroc have developed more serious side-effects. If you experience any of the following, let your doctor know straightaway. These can be signs of a problem with your liver and/or an allergic reaction:

• Loss of appetite, sickness, high temperature (fever), dark urine, stomach pain, extreme tiredness.

• Yellowing of your skin or the whites of the eyes (jaundice).

• Severe itchy skin rash.

Si vous ressentez d'autres symptômes que vous pensez être dus aux comprimés, parlez-en à votre médecin ou à votre pharmacien pour obtenir des conseils supplémentaires.

• Gardez tous les médicaments hors de la portée et de la vue des enfants.

• Conserver dans un endroit frais et sec, à l'abri de la chaleur et de la lumière directes.

• The oral liquid medicine should not be used after 60 days since first opening. Write the date you opened the bottle on the label to remind you.