Abacavir pour le VIH

About abacavir

Abacavir is an antiretroviral medicine. It is used for human immunodeficiency virus (HIV) infection. It slows the progress of HIV infection, but it is not a cure. HIV destroys cells in the body, called CD4 T cells. These cells are a type of white blood cell and are important because they are involved in protecting your body from infection. If left untreated, the HIV infection weakens your immune system so that your body cannot defend itself against bacteria, viruses and other germs. Abacavir slows down the progress of HIV infection by reducing the amount of virus in your body. It does this by stopping the virus from copying (replicating) itself.

Abacavir will be prescribed for you by a doctor who is a specialist. It belongs to a group of antiretroviral medicines known as nucleoside reverse transcriptase inhibitors (NRTIs). It is given alongside a number of other antiretroviral medicines, as part of a combination therapy. Taking three or more antiretroviral medicines at the same time is more effective than taking one alone. Some brands of abacavir contain one or more other antiretroviral medicine - these combination brands help to reduce the total number of tablets you need to take each day. Taking a combination of different medicines reduces the risk that the virus will become resistant to any individual medicine. It is vital to take your antiretroviral medicines exactly as prescribed to maintain success and to help to prevent the virus from becoming resistant to the medicines. These medicines are usually taken for life.

Some medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. For these reasons, before you start taking abacavir it is important that your doctor knows:

• Si vous êtes enceinte, essayez d'avoir un bébé ou allaitez.

• If you have any problems with the way your liver works, or if you have problems with the way your kidneys work.

• If you drink a lot of alcohol.

• Si vous prenez d'autres médicaments. Cela inclut tous les médicaments disponibles à l'achat sans ordonnance, ainsi que les médicaments à base de plantes et les médecines complémentaires.

• Si vous avez déjà eu une réaction allergique à un médicament.

• Before you start the treatment, read the manufacturer's printed information leaflet from inside your pack. It will give you more information about abacavir, and it will also provide you with a full list of the side-effects which you could experience from taking it. There will also be an Alert Card inside your pack. You should keep this with you at all times.

• Take abacavir exactly as your doctor tells you to. The usual dose for adults and older children is 600 mg (two tablets) daily, taken either as a single dose, or divided into two doses, taken morning and evening. Your doctor will tell you how you should take the tablets.

• For younger children, the dose prescribed will depend upon their age. An oral liquid medicine is often prescribed for younger children - check the label on the bottle carefully to make sure that you give the correct dose.

• It is recommended that you swallow the tablets whole with a drink of water. If you have difficulty swallowing tablets, Ziagen® brand tablets can be crushed and added to a drink or a small amount of soft food, providing that you then swallow it straightaway. Alternatively, let your doctor know you have difficulty swallowing the tablets, as the liquid medicine may be more suitable for you.

• Try to take abacavir at the same times of day each day, as this will help you to remember to take your doses regularly. You can take abacavir either with or without food.

• If you forget to take a dose, take it as soon as you remember (unless it is nearly time for your next dose, in which case leave out the missed dose and take the next dose as normal). Do not take two doses together to make up for a forgotten dose.

• Gardez vos rendez-vous réguliers avec votre médecin afin que vos progrès puissent être suivis. Vous devrez effectuer des analyses de sang régulières.

• It is important that you continue to take abacavir and your other antiretroviral treatment regularly. This will help to prevent the HIV from becoming resistant to the medicines you are taking. Even if you miss only a small number of doses, the virus can become resistant to treatment.

• If you develop an infection soon after you start the treatment, let your doctor know. As a result of taking abacavir, your immune system may start fighting an infection which was present before you started the treatment, but which you may not have been aware of.

• Suivez attentivement tous les conseils que votre médecin vous donne concernant les changements de mode de vie pour réduire tout risque de dommage à votre cœur et à vos vaisseaux sanguins. Cela peut inclure l'arrêt du tabac, une alimentation saine et la pratique régulière d'exercice physique.

• Certaines personnes prenant des médicaments antirétroviraux développent des modifications de la répartition de la graisse corporelle dans le corps. Cela peut entraîner des changements dans l'image corporelle. Votre médecin discutera de cette possibilité avec vous.

• Bien que le traitement avec des médicaments antirétroviraux puisse réduire le risque de transmission du VIH à d'autres par contact sexuel, il ne l'élimine pas. Il est important d'utiliser des préservatifs.

• It is not uncommon for people with HIV to feel low or even depressed, especially soon after the diagnosis has been made and treatment has been started. If you have any feelings of depression, or any distressing thoughts about harming yourself then you should speak with your doctor immédiatement.

• Certaines personnes qui ont pris des médicaments antirétroviraux (en particulier sur une longue période) ont développé une affection appelée ostéonécrose. Il s'agit d'une maladie osseuse où le tissu osseux meurt en raison d'une réduction de l'apport sanguin. Cela entraîne des douleurs articulaires et une raideur, et peut causer des difficultés de mouvement. Si vous remarquez l'un de ces symptômes, parlez-en à votre médecin.

• If you buy any medicines, supplements or herbal remedies 'over the counter', check with a pharmacist that they are suitable to take with abacavir and your other medicines. This is because some medicines interfere with antiretrovirals and can stop them from working properly.

• Si vous subissez une opération ou un traitement dentaire, informez la personne qui effectue le traitement des médicaments que vous prenez.

• Treatment for HIV is usually lifelong. Continue to take abacavir regularly, even if you feel well. This is to keep your immune system healthy.

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with abacavir. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.

Abacavir has also been associated with severe allergic reactions (hypersensitivity) and also with a condition called lactic acidosis. Hypersensitivity usually happens within the first six weeks of treatment, although it can occur at any time. Your doctor will screen you before you start treatment, to make sure you are not at high risk of allergic reactions occurring. Lactic acidosis is a condition where a substance called lactic acid builds up in your blood. If you develop any of the symptoms listed below, you must let your doctor know immédiatement, as they can worsen, and may even become life-threatening.

• The most common signs of a serious allergic reaction are fever and a skin rash. Other common symptoms are feeling sick (nausea), diarrhoea, tummy (abdominal) pain, cough or breathing difficulties, feeling weak, sore throat or mouth, headache, and muscle aches and pains.

• The most common signs of lactic acidosis are feeling sick (nausea) or being sick (vomiting), tummy (abdominal) pain, loss of appetite, loss of weight, feeling dizzy, and fast or gasping breathing.

Si vous ressentez d'autres symptômes que vous pensez être dus au médicament, parlez-en à votre médecin ou à votre pharmacien pour obtenir des conseils supplémentaires.

• Gardez tous les médicaments hors de la portée et de la vue des enfants.

• Conserver dans un endroit frais et sec, à l'abri de la chaleur et de la lumière directes.