Rifaximine pour les problèmes hépatiques
Targaxan
Revu par Sid DajaniDernière mise à jour par Michael Stewart, MRPharmSLast updated 19 sept. 2023
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Take one 550 mg tablet, twice daily (Targaxan® brand).
The tablets may make your urine look a pink colour - this is normal and harmless.
The most common side-effects of rifaximin are feeling sick (nausea), feeling dizzy and headache.
At a glance
Rifaximin is an antibiotic taken to prevent episodes of hepatic encephalitis in liver disease.
It helps with symptoms like confusion and changes in alertness caused by hepatic encephalitis.
Take rifaximin exactly as prescribed by your doctor, usually one tablet twice a day.
Common side-effects can include feeling sick, tummy discomfort, dizziness, or headache.
If you experience troublesome side-effects or other symptoms, discuss them with your doctor.
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About rifaximin
Type de médicament | A rifamycin antibiotic |
Utilisé pour | To prevent episodes of hepatic encephalitis in liver disease |
Aussi appelé | Targaxan® |
Disponible sous forme de | Comprimés |
Rifaximin is an antibiotic which works within the gastrointestinal system. It is given to help prevent episodes of a problem called hepatic encephalitis in people with liver disease. Hepatic encephalitis can cause a range of symptoms. These include confusion, personality changes, and changes in alertness.
Another brand of rifaximin tablets, called Xifaxanta®, is used to treat traveller's diarrhoea. If you have been prescribed it for this reason, please see the separate leaflet called Rifaximine pour la diarrhée du voyageur.
Before taking rifaximin
Retour au sommaireSome medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking rifaximin it is important that your doctor knows:
Si vous êtes enceinte, essayez d'avoir un bébé, ou allaitez.
If you are very constipated or think you may have a blocked bowel.
Si vous avez déjà eu une réaction allergique à un médicament.
Si vous prenez d'autres médicaments. Cela inclut tous les médicaments que vous prenez et qui sont disponibles à l'achat sans ordonnance, ainsi que les médicaments à base de plantes et les médecines complémentaires.
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How to take rifaximin
Retour au sommaireBefore you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about rifaximin and will provide you with a full list of the side-effects which you may experience from taking it.
Take rifaximin exactly as your doctor tells you to. The usual dose is one 550 mg tablet twice daily.
Swallow the tablets with a drink of water. It is not important whether you take your dose before or after food. The tablets may make your urine look a pink colour - this is harmless.
If you forget to take a dose, take it as soon as you remember. If when you remember, it is nearly time for your next dose then leave out the missed dose and take your next dose when it is due. Do not take two doses together to make up for a forgotten dose.
Tirer le meilleur parti de votre traitement
Retour au sommaireRemember to keep your regular appointments with your doctor. This is so your doctor can check on your progress.
Continue to take rifaximin unless your doctor tells you to stop. Otherwise your symptoms may return.
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Can rifaximin cause problems?
Retour au sommaireAlong with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with rifaximin when taken for liver problems. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.
Common rifaximin side-effects (ces effets touchent moins de 1 personne sur 10) | Que puis-je faire si je ressens cela ? |
Feeling sick (nausea), gastrointestinal upset, tummy (abdominal) discomfort | Optez pour des aliments simples - évitez les repas riches ou épicés |
Sensation de vertige | Do not drive and do not use tools or machines while you feel dizzy |
Maux de tête | Drink plenty of water and ask your doctor to recommend a suitable painkiller |
Feeling depressed, feeling short of breath, itchy rash, swollen feet or ankles, muscle cramps or pains | Si l'un de ces éléments devient problématique, discutez-en avec votre médecin |
Si vous ressentez d'autres symptômes que vous pensez être dus aux comprimés, parlez-en à votre médecin ou à votre pharmacien pour obtenir des conseils supplémentaires.
How to store rifaximin
Retour au sommaireGardez tous les médicaments hors de la portée et de la vue des enfants.
Conserver dans un endroit frais et sec, à l'abri de la chaleur et de la lumière directes.
Informations importantes sur tous les médicaments
Retour au sommaireInformations importantes sur tous les médicaments
Ne prenez jamais plus que la dose prescrite. Si vous soupçonnez que vous ou quelqu'un d'autre avez pris une surdose de ce médicament, rendez-vous au service des urgences de votre hôpital local. Emportez le contenant avec vous, même s'il est vide.
Ce médicament est pour vous. Ne le donnez jamais à d'autres personnes, même si leur état semble être le même que le vôtre.
Si vous subissez une opération ou un traitement dentaire, informez la personne qui effectue le traitement des médicaments que vous prenez.
If you buy any medicines, always check with a pharmacist that they are suitable for you to take with your other medicines.
Ne gardez pas de médicaments périmés ou indésirables. Apportez-les à votre pharmacie locale qui s'en débarrassera pour vous.
Si vous avez des questions concernant ce médicament, demandez à votre pharmacien.
Signaler les effets secondaires d'un médicament ou d'un vaccin
Si vous ressentez des effets secondaires, vous pouvez les signaler en ligne via le Yellow Card website.

Vous n'êtes pas sûr de mélanger des médicaments ?
Vérifiez les interactions possibles entre les médicaments, les compléments et les aliments avant de les prendre ensemble.
Questions fréquemment posées
What is hepatic encephalitis and why is rifaximin prescribed for it?
Hepatic encephalitis is a problem that can occur in people with liver disease, causing symptoms such as confusion, personality changes, and altered alertness. Rifaximin is an antibiotic that works within the gastrointestinal system to help prevent these episodes.
Why is it important to tell my doctor about other medicines I am taking?
It's important to inform your doctor about all medicines you are taking, including those bought without a prescription, herbal remedies, and complementary medicines. This is because some medicines are not suitable to be taken together or may require extra care, to avoid potential interactions or complications with rifaximin.
Can I take rifaximin with or without food?
It doesn't matter whether you take your dose of rifaximin before or after food. You should swallow the tablets with a drink of water.
What should I do if I forget to take a dose of rifaximin?
If you forget a dose, take it as soon as you remember. If it's nearly time for your next dose when you remember, then you should skip the missed dose and take your next dose as usual. Do not take two doses at once to compensate for a forgotten one.
How long will I need to keep taking rifaximin?
You should continue to take rifaximin for as long as your doctor advises. Stopping the medication earlier than instructed could lead to your symptoms returning.
Is it normal for rifaximin to change the colour of my urine?
Yes, the tablets may cause your urine to appear pink. This is a harmless side effect.
What should I do if my side effects don't go away or become bothersome?
While many common side effects like feeling sick, tummy discomfort, or dizziness often improve as your body adjusts, you should speak with your doctor or pharmacist if any side effects continue, become troublesome, or if you experience any other symptoms you think might be due to the tablets.
Lectures complémentaires et références
- Manufacturer's PIL, Targaxan® 550 mg film-coated tablets; Norgine Limited, The electronic Medicines Compendium. Dated March 2021.
- Médicaments Complets BNF 89e Édition; Association Médicale Britannique et Société Royale Pharmaceutique de Grande-Bretagne, Londres.
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About the authorView full bio

Michael Stewart, MRPharmS
Medicine Leaflet Review Manager – Contractor, Pharmacist
BPharm (Hons), MRPharmS
Michael is a community pharmacist practicing in the Midlands and South Yorkshire with more than 20 years’ experience advising on medicines and medical conditions. He has a strong background in healthcare training, having produced and delivered training courses for pharmacy teams and staff of residential care settings, including nurses. He has also contributed to pharmacy advisory boards for the management of low acuity conditions in the community.
About the reviewer

Sid Dajani
Sultan Dajani qualified at the London School of Pharmacy in 1994 and became the youngest elected member of the Royal Pharmaceutical Society council since its founding in 1842.
Historique de l'article
Les informations sur cette page sont rédigées et examinées par des cliniciens qualifiés.
Prochaine révision prévue : 18 sept. 2026
19 sept. 2023 | Dernière version

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