Rabéprazole pour réduire l'acidité gastrique
Pariet
Revu par Sid DajaniDernière mise à jour par Michael Stewart, MRPharmSDernière mise à jour 2 juin 2024
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Rabeprazole reduces the amount of acid produced in your stomach.
Swallow the tablet whole - do not chew or crush it before you swallow.
Any side-effects are usually mild in nature and do not last for long.
En un coup d'œil
Rabeprazole is a medicine known as a proton pump inhibitor, used to reduce stomach acid.
It treats conditions like ulcers, acid reflux, and H. pylori infection.
Take Rabeprazole tablets whole with water, as directed by your doctor.
It can be taken before or after food, but before food is preferred.
Common side effects include headache, dizziness, nausea, stomach ache, and diarrhoea.
See your doctor if you develop a blistering skin rash and joint pain while taking this medicine.
About rabeprazole
Type de médicament | Proton pump inhibitor |
Utilisé pour | Gastric and duodenal ulcers; gastro-oesophageal reflux disease; |
Aussi appelé | Pariet® |
Disponible sous forme de | Comprimés |
Acid is produced naturally in your stomach to help you digest food and to kill germs (bacteria). This acid is irritant so your body produces a natural mucous barrier which protects the lining of your stomach. In some people, this barrier can break down allowing the acid to damage the stomach, causing inflammation, ulcers and other conditions. Other people can have a problem with the muscular band at the top of the stomach that keeps the stomach tightly closed. This may allow the acid to escape and irritate the oesophagus, causing heartburn. This is often referred to as 'acid reflux'.
Inhibiteurs de la pompe à protons such as rabeprazole stop cells in the lining of the stomach from producing too much acid. This helps to prevent des ulcères from forming, or assists the healing process where damage has already occurred. By decreasing the amount of acid, they can also help to reduce the symptoms of acid reflux disease, such as heartburn.
Rabeprazole is also used as one part of a treatment to get rid of Helicobacter pylori, a bacterium found in the stomach, which can cause ulcers.
Before taking rabeprazole
Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking rabeprazole it is important that your doctor knows:
Si vous êtes enceinte, essayez d'avoir un bébé ou allaitez.
If you have any of the following symptoms: difficulty swallowing, loss of blood, weight loss, or if you are being sick.
Si vous avez des problèmes avec le fonctionnement de votre foie ou de vos reins.
If you have weakened bones due to osteoporosis or you are at risk of developing osteoporosis.
If you have any problems with the way your body absorbs certain vitamins or minerals from your food.
Si vous avez une affection inflammatoire appelée lupus érythémateux systémique (également appelé lupus, ou LES).
Si vous avez déjà eu une réaction allergique à un médicament.
Si vous prenez d'autres médicaments. Cela inclut tous les médicaments que vous prenez et qui sont disponibles à l'achat sans ordonnance, ainsi que les médicaments à base de plantes et les médecines complémentaires.
How to take rabeprazole
Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about rabeprazole and will provide you with a full list of the side-effects which you may experience from taking it.
Take rabeprazole exactly as your doctor tells you to. Rabeprazole is commonly taken just once a day, in the morning. If you are taking it for either Helicobacter pylori eradication or for Zollinger-Ellison syndrome, you could be asked to take two doses a day. Your doctor will tell you which dose is right for you, and the directions will also be printed on the label of the pack to remind you about what the doctor said.
Swallow the tablet with a drink of water. Do not chew, crush or break the tablet before you swallow. Rabeprazole tablets have a special coating so you should swallow them whole.
Rabeprazole can be taken either before or after food, although taking it before food is preferable.
If you forget to take a dose at your usual time, you can generally take it when you remember. However, if it is nearly time to take your next dose when you remember, leave out the missed dose and take your next dose when it is due. Do not take two doses together to make up for a forgotten dose.
Tirer le meilleur parti de votre traitement
Try to keep your regular appointments with your doctor. This is so your progress can be checked. If you are taking rabeprazole on a long-term basis your doctor will want to review your treatment at least once a year to make sure it is still right for you.
A typical course of treatment lasts for one or two weeks if you are taking rabeprazole for Helicobacter pylori eradication. It will last for one or two months if it is to allow an ulcer to heal. For all other reasons for taking rabeprazole, your treatment will last for as long as is necessary to control your symptoms.
Some foods may make your symptoms worse. Foods and drinks that have been suspected of this include peppermint, tomatoes, chocolate, spicy foods, hot drinks, coffee and alcoholic drinks. If it seems that a food is aggravating your symptoms, try avoiding it for a while to see if your symptoms improve. Also, try avoiding eating large meals, as these can make your symptoms worse too.
If you are overweight, it puts extra pressure on your stomach and encourages the symptoms of acid reflux. Losing some weight and eating a healthy balanced diet may help you.
Smoking increases the amount of acid produced by the stomach and may make your symptoms worse. If you are a smoker, speak with your doctor or pharmacist about how to quit.
Recent studies suggest that there may be a slight increase in the risk of bone fractures when proton pump inhibitors like rabeprazole are taken for longer than a year. If this affects you, your doctor will check that you are taking enough vitamin D and calcium to reduce this risk.
If you buy any medicines 'over the counter', always check with a pharmacist that they are safe to take alongside your other medicines.
Can rabeprazole cause problems?
Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with rabeprazole. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.
Common rabeprazole side-effects (these affect fewer than 1 in 10 people) | Que puis-je faire si je ressens cela ? |
Maux de tête | Buvez beaucoup d'eau et demandez à votre pharmacien de vous recommander un antidouleur approprié. Si les maux de tête persistent, informez votre médecin |
Se sentir étourdi ou fatigué | Getting up or moving more slowly may help dizziness. Do not drive and do not use tools or machines until you feel better |
Feeling sick (nausea), stomach ache, or wind | Optez pour des repas simples - évitez les aliments riches ou épicés |
Diarrhée | Drink plenty of water. If it continues or becomes severe, let your doctor know |
Constipation | Essayez de manger un régime équilibré et de boire plusieurs verres d'eau chaque jour |
Flu-like infections, cough, runny or stuffy nose, difficulty sleeping, and back pain | Si l'un de ces éléments devient problématique, parlez-en à votre médecin |
Important: in very rare cases rabeprazole has caused a skin condition called cutaneous lupus erythematosus (CLE). See your doctor if you develop a blistering skin rash together with joint pain, either during or after treatment with rabeprazole.
Si vous ressentez d'autres symptômes que vous pensez être dus aux comprimés, parlez-en à votre médecin ou à votre pharmacien pour obtenir des conseils supplémentaires.
How to store rabeprazole
Gardez tous les médicaments hors de la portée et de la vue des enfants.
Conserver dans un endroit frais et sec, à l'abri de la chaleur et de la lumière directes.
Informations importantes sur tous les médicaments
Informations importantes sur tous les médicaments
Ne prenez jamais plus que la dose prescrite. Si vous soupçonnez que vous ou quelqu'un d'autre avez pris une surdose de ce médicament, rendez-vous au service des urgences de votre hôpital local. Emportez le contenant avec vous, même s'il est vide.
Ce médicament est pour vous. Ne le donnez jamais à d'autres personnes, même si leur état semble être le même que le vôtre.
Si vous subissez une opération ou un traitement dentaire, informez la personne qui effectue le traitement des médicaments que vous prenez.
Ne gardez pas de médicaments périmés ou indésirables. Apportez-les à votre pharmacie locale qui s'en débarrassera pour vous.
Si vous avez des questions concernant ce médicament, demandez à votre pharmacien.
Signaler les effets secondaires d'un médicament ou d'un vaccin
Si vous ressentez des effets secondaires, vous pouvez les signaler en ligne via le Site web de Yellow Card.

Vous n'êtes pas sûr de mélanger des médicaments ?
Vérifiez les interactions possibles entre les médicaments, les compléments et les aliments avant de les prendre ensemble.
Questions fréquemment posées
What should I do if I miss a dose of rabeprazole?
If you forget to take your rabeprazole dose at the usual time, you can generally take it when you remember. However, if it's almost time for your next scheduled dose, you should skip the missed dose and take your next one as planned. Do not take two doses at once to make up for a forgotten dose.
How long will I need to take rabeprazole?
The duration of your rabeprazole treatment depends on why you are taking it. If it's for Helicobacter pylori eradication, a typical course lasts one to two weeks. If it's to heal an ulcer, treatment will last one to two months. For other conditions, you will take rabeprazole for as long as needed to control your symptoms.
Are there any lifestyle changes I can make to help my condition while taking rabeprazole?
Yes, some lifestyle changes can help. Certain foods like peppermint, tomatoes, chocolate, spicy foods, hot drinks, coffee, and alcoholic drinks can worsen symptoms, so you might try avoiding them. Eating smaller meals can also help. If you are overweight, losing weight can reduce pressure on your stomach. Smoking increases stomach acid, so quitting can also improve your symptoms.
Can rabeprazole affect my bones?
Recent studies suggest a small increase in the risk of bone fractures if proton pump inhibitors like rabeprazole are taken for more than a year. If this applies to you, your doctor will check if you are getting enough vitamin D and calcium to help reduce this risk.
What unusual skin condition has been linked to rabeprazole?
In very rare cases, rabeprazole has been associated with a skin condition called cutaneous lupus erythematosus (CLE). If you develop a blistering skin rash along with joint pain, either during or after your treatment with rabeprazole, you should see your doctor.
Lectures complémentaires et références
- Manufacturer's PIL, Pariet® 10 mg and 20 mg Tablets; Eisai Limited, The electronic Medicines Compendium. Dated March 2023.
- Médicaments Complets BNF 89e Édition; Association Médicale Britannique et Société Royale Pharmaceutique de Grande-Bretagne, Londres.
À propos de l'auteurVoir la biographie complète

Michael Stewart, MRPharmS
Responsable de l'examen des notices de médicaments – Contractuel, Pharmacien
BPharm (Hons), MRPharmS
Michael est un pharmacien communautaire exerçant dans les Midlands et le South Yorkshire avec plus de 20 ans d'expérience dans le conseil sur les médicaments et les conditions médicales. Il possède une solide expérience en formation dans le domaine de la santé, ayant produit et dispensé des cours de formation pour les équipes de pharmacie et le personnel des établissements de soins résidentiels, y compris les infirmières. Il a également contribué aux comités consultatifs de pharmacie pour la gestion des affections de faible gravité dans la communauté.
À propos du critique

Sid Dajani
Sultan Dajani a obtenu son diplôme à la London School of Pharmacy en 1994 et est devenu le plus jeune membre élu du conseil de la Royal Pharmaceutical Society depuis sa fondation en 1842.
Historique de l'article
Les informations sur cette page sont rédigées et examinées par des cliniciens qualifiés.
Article également disponible en Anglais, Allemand, Espagnol, Français, Italien, Portugais, Hindi, Hébreu, Arabe, and Suédois.
Prochaine révision prévue : 15 mai 2027
2 juin 2024 | Dernière version

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