Moclobémide

About moclobemide

Moclobemide is a type of antidepressant that is prescribed for people with depression or social anxiety disorder, particularly if other treatments have proved unsuccessful.

Moclobemide works by interfering with brain chemicals, called neurotransmitters. It works by reducing the action of an enzyme called monoamine oxidase A. By doing this, it increases the levels of the neurotransmitters, serotonin, dopamine and noradrenaline. Altering the balance of these brain chemicals can help with the symptoms of depression and social anxiety disorder.

Dépression can develop for no apparent reason, or it can be triggered by a life event such as a relationship problem, a bereavement, or an illness. Trouble d'anxiété sociale is also known as social phobia - it is a fear of behaving in an embarrassing way whilst talking or meeting with other people.

The most common side effects of moclobemide are:

• Sensation de vertige.

• Bouche sèche.

• Se sentir mal.

• Diarrhée.

• Constipation.

• Maux de tête.

• Difficulté à dormir.

• Se sentir agité ou irritable.

• Tingling sensations.

Vous trouverez une liste complète dans la notice d'information du fabricant fournie avec votre médicament. Les effets indésirables s'améliorent souvent à mesure que votre corps s'adapte au nouveau médicament, mais parlez-en à votre médecin ou pharmacien si l'un des effets suivants persiste ou devient gênant.

Si vous ressentez d'autres symptômes que vous pensez être dus aux comprimés, parlez-en à votre médecin ou à votre pharmacien pour obtenir des conseils supplémentaires.

Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking moclobemide it is important that your doctor knows:

• Si vous êtes enceinte, essayez d'avoir un bébé ou allaitez.

• If you have thyroid problems.

• Si vous avez des problèmes avec le fonctionnement de votre foie.

• If you have bipolar disorder or are feeling particularly agitated or confused.

• If you have been told you have a tumour on your adrenal gland, called phaeochromocytoma.

• Si vous avez déjà eu une réaction allergique à un médicament.

• Si vous prenez d'autres médicaments. Cela inclut tous les médicaments que vous prenez et qui sont disponibles à l'achat sans ordonnance, ainsi que les médicaments à base de plantes et les médecines complémentaires.

• Read the manufacturer's printed information leaflet from inside the pack and any additional printed information you are given.

  • The leaflets will give you more information about moclobemide and will provide you with a full list of the side effects which you may experience from taking it.

• Take moclobemide exactly as your doctor tells you to. It is usual to be prescribed two doses to take a day. You may be asked to take one or two tablets for each of your doses.

  • There are two strengths of tablet available - 150 mg and 300 mg.

• Take moclobemide with a meal, or just after a snack.

• Si vous oubliez de prendre une dose, prenez-la dès que vous vous en souvenez (sauf s'il est presque l'heure de votre prochaine dose, auquel cas laissez de côté la dose oubliée). Ne prenez pas deux doses ensemble pour compenser une dose oubliée.

• Essayez de respecter vos rendez-vous réguliers avec votre médecin. Cela permet à votre médecin de suivre vos progrès.

• Some people who take moclobemide can be sensitive to a substance called tyramine which is present in some foods and alcoholic drinks.

  • You should avoid eating large amounts of food such as mature cheese, yeast extracts such as Marmite®, Oxo® and Bovril®, and fermented soya bean extract (an ingredient in some Chinese food).

• When you first start taking moclobemide, you may have thoughts about harming yourself or ending your life. These thoughts can be associated with your condition. It is very important that you tell your doctor about this if it happens.

• Continue to take moclobemide unless your doctor tells you otherwise. Stopping treatment suddenly can sometimes cause problems and your doctor will probably want you to reduce your dose gradually if this becomes necessary.

  • Your doctor may ask you to carry on taking moclobemide even after you feel better. This is normal and helps to prevent your symptoms from recurring.

• Check with a pharmacist before you buy or take any other medicines, to make sure that they are safe to take with moclobemide. Some commonly used cough and cold remedies and some painkillers must not be taken with moclobemide.

• If you are having an operation or dental treatment, tell the person carrying out the treatment that you are taking moclobemide.

• Gardez tous les médicaments hors de la portée et de la vue des enfants.

• Conserver dans un endroit frais et sec, à l'abri de la chaleur et de la lumière directes.

Why are MAOIs a 'last resort' antidepressant?

MAOIs are usually considered a last-resort antidepressant because they can interact with certain foods and other medications, which can lead to serious side effects. They are often only prescribed when other antidepressants haven’t worked, as newer options tend to be safer and easier to manage

Is moclobemide good for anxiety?

Moclobemide can help with some anxiety disorders, especially social or generalised anxiety, however it is mainly prescribed for depression.