Passer au contenu principal

Capsules de linaclotide

Constella

Take one capsule once daily.

Take the capsule at least half an hour before food.

The most common side-effect is diarrhoea. Let your doctor know if this becomes severe or lasts for longer than a week.

At a glance

  • Linaclotide is a medicine for adults with constipation related to irritable bowel syndrome.

  • It helps to increase bowel secretions and movement, making stools easier to pass.

  • Take one capsule daily, at least 30 minutes before food.

  • Diarrhoea is a common side-effect; if severe or long-lasting, tell your doctor.

  • Inform your doctor if you experience any bleeding from your back passage.

  • Keep the capsules in their original container, and discard them after 18 weeks of opening.

Continuez à lire ci-dessous

About linaclotide

Type de médicament

Guanylate cyclase-C receptor agonist

Utilisé pour

Constipation associated with irritable bowel syndrome in adults

Aussi appelé

Constella®

Disponible sous forme de

Capsules

Syndrome de l'intestin irritable (SII) is a common disorder. Symptoms can be quite variable, and can come and go. Typical symptoms include tummy (abdominal) pain, bloating, and bouts of constipation and/or diarrhoea. Linaclotide can be useful for people who have de la constipation as one of the main symptoms of IBS. It helps to increase bowel secretions and movement, making stools easier to pass, and it also helps to ease pain and discomfort.

Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking linaclotide it is important that your doctor knows:

  • Si vous êtes enceinte ou si vous allaitez.

  • Si vous êtes tellement constipé que vous pensez avoir une obstruction.

  • Si vous avez déjà eu une réaction allergique à un médicament.

  • Si vous prenez d'autres médicaments. Cela inclut tous les médicaments que vous prenez et qui sont disponibles à l'achat sans ordonnance, ainsi que les médicaments à base de plantes et les médecines complémentaires.

Continuez à lire ci-dessous

  • Before you start this treatment, read the manufacturer's printed information leaflet from inside your pack. It will give you more information about linaclotide and will provide you with a full list of the side-effects which you may experience from taking it.

  • Take linaclotide exactly as your doctor tells you to. It is taken once daily. You can take your dose at a time of day that suits you, but try to take it at around the same time of day, each day.

  • Swallow the capsule whole with a drink of water. It is best taken on an empty stomach (which means at least 30 minutes before food). This is because taking the capsules with food increases the possibility that diarrhoea will occur.

  • Si vous oubliez de prendre une dose, prenez-la dès que vous vous en souvenez. Si vous ne vous en souvenez que le lendemain, sautez la dose oubliée. Ne prenez pas deux doses en même temps pour compenser une dose manquée.

  • Essayez de respecter vos rendez-vous réguliers avec votre médecin. Cela permet à votre médecin de suivre vos progrès.

  • A healthy diet containing fibre (wholegrain breads and cereals, bran, fruit and green leafy vegetables) with several glasses of water each day and daily exercise are important in maintaining healthy bowel function.

  • You can read our leaflet called Fibre and Fibre Supplements for advice on ways to increase the amount of fibre in your diet.

Continuez à lire ci-dessous

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with linaclotide. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.

Common linaclotide side-effects

Que puis-je faire si je ressens cela ?

Diarrhée

Drink plenty of water, and make sure that you take the capsules at least 30 minutes before food. If the diarrhoea is severe or continues for more than a week, let your doctor know

Wind, tummy (abdominal) discomfort

Si cela pose problème, parlez-en à votre médecin

Sensation de vertige

Do not drive and do not use tools or machines while you feel dizzy

If you notice any bleeding from your back passage whilst taking linaclotide, let your doctor know. This could be due to piles (haemorrhoids) caused by your constipation or due to the treatment itself.

Si vous ressentez d'autres symptômes que vous pensez être dus au médicament, parlez-en à votre médecin ou à votre pharmacien pour obtenir des conseils supplémentaires.

  • Gardez tous les médicaments hors de la portée et de la vue des enfants.

  • Store in a cool, dry place, away from direct heat and light. The capsules can absorb moisture from the air so it is important to keep them in their original container (which contains a desiccant to keep them dry). Do not keep the capsules for longer than 18 weeks after the container is first opened.

Informations importantes sur tous les médicaments

Ne prenez jamais plus que la dose prescrite. Si vous soupçonnez que vous ou quelqu'un d'autre avez pris une surdose de ce médicament, rendez-vous au service des urgences de votre hôpital local. Emportez le contenant avec vous, même s'il est vide.

Ce médicament est pour vous. Ne le donnez jamais à d'autres personnes, même si leur état semble être le même que le vôtre.

If you are having an operation or dental treatment, tell the person carrying out the treatment what medicines you are taking.

If you buy any medicines, always check with a pharmacist that they are suitable for you to take with your other medicines.

Ne gardez pas de médicaments périmés ou indésirables. Apportez-les à votre pharmacie locale qui s'en débarrassera pour vous.

Si vous avez des questions concernant ce médicament, demandez à votre pharmacien.

Signaler les effets secondaires d'un médicament ou d'un vaccin

Si vous ressentez des effets secondaires, vous pouvez les signaler en ligne via le Yellow Card website.

symptom checker

Vous n'êtes pas sûr de mélanger des médicaments ?

Vérifiez les interactions possibles entre les médicaments, les compléments et les aliments avant de les prendre ensemble.

Questions fréquemment posées

What is linaclotide and how does it help with IBS-related constipation?

Linaclotide is a type of medicine called a guanylate cyclase-C receptor agonist. It is used to treat constipation that is associated with irritable bowel syndrome (IBS) in adults. It works by increasing bowel secretions and movement, which makes stools easier to pass. Additionally, it helps to reduce tummy pain and discomfort.

When is the best time of day to take linaclotide capsules?

You can take linaclotide capsules at a time of day that suits your routine. However, it's recommended to take it at approximately the same time each day. It should be taken on an empty stomach, at least 30 minutes before food, as taking it with food can increase the likelihood of experiencing diarrhoea.

What should I do if I forget to take a dose?

If you forget to take a dose, you should take it as soon as you remember. If you don't remember until the next day, you should skip the missed dose and continue with your regular schedule. Do not take two doses at the same time to compensate for a forgotten dose.

How can I store linaclotide properly to ensure it remains effective?

Linaclotide capsules should be kept in their original container, away from direct heat and light, in a cool, dry place. The container includes a desiccant to prevent the capsules from absorbing moisture from the air. It's important not to keep the capsules for longer than 18 weeks once the container has been opened.

Are there any natural ways to support my bowel health while taking linaclotide?

Yes, alongside taking linaclotide, maintaining a healthy diet that includes fibre-rich foods such as wholegrain breads, cereals, bran, fruit, and green leafy vegetables can help. Drinking several glasses of water daily and engaging in regular exercise are also important for healthy bowel function.

What should I do if I experience severe or persistent diarrhoea?

Diarrhoea is a common side-effect of linaclotide. You should drink plenty of water to stay hydrated and ensure you are taking the capsules at least 30 minutes before food. If the diarrhoea becomes severe or lasts for more than a week, you should inform your doctor.

Can I take linaclotide if I'm pregnant or breastfeeding?

Before starting linaclotide, you must inform your doctor if you are pregnant or breastfeeding. They will need to consider this information to determine if the medicine is suitable for you.

Lectures complémentaires et références

Continuez à lire ci-dessous

About the authorView full bio

Author image

Michael Stewart, MRPharmS

Medicine Leaflet Review Manager – Contractor, Pharmacist

BPharm (Hons), MRPharmS

Michael is a community pharmacist practicing in the Midlands and South Yorkshire with more than 20 years’ experience advising on medicines and medical conditions. He has a strong background in healthcare training, having produced and delivered training courses for pharmacy teams and staff of residential care settings, including nurses. He has also contributed to pharmacy advisory boards for the management of low acuity conditions in the community.

About the reviewer

Author image

Sid Dajani

Sultan Dajani qualified at the London School of Pharmacy in 1994 and became the youngest elected member of the Royal Pharmaceutical Society council since its founding in 1842.

Historique de l'article

Les informations sur cette page sont rédigées et examinées par des cliniciens qualifiés.

  • Prochaine révision prévue : 18 sept. 2026
  • 19 sept. 2023 | Dernière version

    Dernière mise à jour par

    Michael Stewart, MRPharmS

    Revu par

    Sid Dajani
flu eligibility checker

Demandez, partagez, connectez-vous.

Parcourez les discussions, posez des questions et partagez vos expériences sur des centaines de sujets de santé.

Inscrivez-vous à la newsletter Patient

Votre dose hebdomadaire de conseils de santé clairs et fiables - rédigés pour vous aider à vous sentir informé, confiant et maître de la situation.

Veuillez entrer une adresse e-mail valide

By subscribing you accept our Politique de confidentialité. Vous pouvez vous désabonner à tout moment. Nous ne vendons jamais vos données.