Olanzapine en injection à action prolongée
Zypadhera
Révision par Sid DajaniDernière mise à jour par Michael Stewart, MRPharmSDernière mise à jour le 12 décembre 2022
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Olanzapine long-acting injection will be given to you by your clinic doctor or nurse every 2-4 weeks.
The injection may cause you to feel sleepy or dizzy for a few hours afterwards.
Si vous manquez un rendez-vous pour une injection, prenez-en un autre dès que possible.
There are a number of side-effects which you could experience from the treatment. If you are concerned about any, you should discuss them with your doctor.
Dans cet article :
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About olanzapine long-acting injection
Type de médicament | Une injection d'antipsychotique |
Utilisé pour | Maintien du contrôle des symptômes chez les adultes atteints de schizophrénie et d'autres problèmes de santé mentale similaires |
Également appelé | Zypadhera® (olanzapine embonate) |
Disponible en | Long-acting depot injection |
Olanzapine belongs to a group of medicines called antipsychotics. You will have been prescribed it to maintain symptom control of schizophrenia.
Schizophrenia is a mental health condition that causes disordered ideas, beliefs and experiences. Symptoms of schizophrenia include hearing, seeing, or sensing things that are not real, having mistaken beliefs, feeling unusually suspicious, and becoming withdrawn. Olanzapine is used to relieve the symptoms of schizophrenia and other similar mental health problems. It works on the balance of chemical substances in your brain.
Long-acting, or 'depot', injections are used once your symptoms have been eased by taking tablets. The injection slowly releases olanzapine into your body and is given either every two weeks, or every four weeks. The main advantage of a depot injection is that you do not have to remember to take tablets every day.
Before having olanzapine long-acting injection
Some medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. For these reasons, before you start having olanzapine long-acting injections, it is important that your doctor knows:
Si vous êtes enceinte ou si vous allaitez.
Si vous souffrez d'une maladie cardiaque ou d'une maladie des vaisseaux sanguins.
Si vous avez des problèmes de fonctionnement du foie ou des reins.
Si vous avez des problèmes de prostate.
Si vous avez des problèmes respiratoires.
If you have any of the following: epilepsy, diabetes (diabetes mellitus), depression, Parkinson's disease, raised pressure in your eye (glaucoma) or a condition which causes muscle weakness, called myasthenia gravis.
If you have ever had yellowing of your skin or the whites of your eyes (jaundice).
If you have a blood or bone marrow disorder.
If you are very constipated or think you may have a blockage in your bowel.
Si vous avez eu une réaction allergique à un médicament.
Si vous prenez ou utilisez d'autres médicaments. Cela comprend tous les médicaments que vous prenez et qui sont disponibles sans ordonnance, ainsi que les médicaments à base de plantes et les médicaments complémentaires.
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How olanzapine long-acting injection is given
Before you start the treatment, ask to read the manufacturer's printed information leaflet from inside the pack. The leaflet will give you more information about olanzapine, and it will also provide you with a full list of the side-effects which you could experience.
Olanzapine long-acting injection will be given to you in an outpatient clinic by a doctor or nurse. The injection is given into a muscle in your bottom (buttocks). As a routine, you will be asked to stay in the clinic where you can be observed for at least three hours after each injection. This is because it can make you feel tired or dizzy after it is given. You will be advised not to drive and not to use tools or machines for the remainder of the day.
You may be asked to continue taking your current tablets for a short while after you have had your first injection. This is because it can take a few weeks before you feel the full effect from the injection.
Treatment with olanzapine is usually long-term so that your symptoms don't return.
Tirer le meilleur parti de votre traitement
Your treatment will require careful monitoring to make sure that you get the best possible benefit from olanzapine. Keep your regular doctor's appointments so that you get your injections on time, and your progress can be checked. If you miss an appointment for an injection, contact the hospital to arrange for another appointment as soon as possible.
Olanzapine could cause your skin to become more sensitive to sunlight than normal. Avoid strong sunlight and sunbeds, and use a sun cream with a high sun protection factor even on bright but cloudy days.
If you drink alcohol, ask your doctor for advice about drinking while you are on olanzapine. Alcohol can increase the chance that you will experience side-effects and may not be advisable for you.
If you have diabetes you may need to check your blood sugar (glucose) more frequently, as olanzapine can affect the levels of sugar in your blood. Your doctor will advise you about this.
If you are having any dental treatment or an operation, tell the person carrying out the treatment that you have had an olanzapine injection. This is important because it may interfere with the anaesthetic you receive.
If you buy or take any 'over-the-counter' medicines, check with a pharmacist that they are suitable for you to take with olanzapine.
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Can olanzapine long-acting injection cause problems?
Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the more common ones associated with olanzapine. The best place to find a full list of the side-effects which can be associated with your medicine, is from the manufacturer's printed information leaflet supplied with the medicine. Alternatively, you can find an example of a manufacturer's information leaflet in the reference section below. Speak with your doctor or pharmacist if any of the following continue or become troublesome.
Very common olanzapine side-effects (these affect more than 1 in 10 people) | Que puis-je faire si je suis confronté à cette situation ? |
Feeling sleepy, tired or dizzy | Ne pas conduire et ne pas utiliser d'outils ou de machines pendant la durée de l'affection. |
Augmentation du poids | Eat a well-balanced diet. Speak with your doctor if your weight becomes troublesome |
Modification de certains résultats d'analyses sanguines | Votre médecin surveillera les éléments suivants |
Common olanzapine side-effects (ces maladies touchent moins d'une personne sur dix) | Que puis-je faire si je suis confronté à cette situation ? |
Feeling restless | Parlez-en à votre médecin |
Douleur au point d'injection | Cela ne devrait pas durer longtemps. Si la zone devient rouge, gonflée ou bosselée, informez-en votre médecin. |
Bouche sèche | Essayez de mâcher du chewing-gum sans sucre ou de sucer des bonbons sans sucre. |
Constipation | Drink plenty of water, and eat a well-balanced diet containing plenty of fruit, vegetables, and fibre |
Unusual or uncontrollable muscle movements, shakiness | Parlez-en à votre médecin |
Increased appetite and weight, rash, feeling hot, reduced interest in sex, erectile dysfunction, aches and pains | Discutez-en avec votre médecin si l'un d'entre eux devient gênant. |
ImportantSi vous présentez des symptômes tels qu'une raideur musculaire, une température très élevée, une sensation de confusion ou de transpiration, un rythme cardiaque rapide et une incontinence urinaire, vous devez immédiatement contacter votre médecin. Ces symptômes peuvent être le signe d'une maladie rare mais grave appelée syndrome malin des neuroleptiques.
Si vous ressentez d'autres symptômes qui pourraient être dus à l'injection, demandez conseil à votre médecin ou à votre pharmacien.
Informations importantes sur tous les médicaments
Informations importantes sur tous les médicaments
If you suspect that you have had an overdose of this medicine, go to the accident and emergency department of your local hospital at once.
Ce médicament est pour vous. Ne le donnez jamais à d'autres personnes, même si leur état semble être le même que le vôtre.
Ne gardez pas les médicaments périmés ou dont vous ne voulez plus. Apportez-les à votre pharmacie locale qui les éliminera pour vous.
Si vous avez des questions sur ce médicament, demandez à votre pharmacien.
Signaler les effets secondaires d'un médicament ou d'un vaccin
Si vous ressentez des effets secondaires, vous pouvez les signaler en ligne sur le site web de la carte jaune.
Autres lectures et références
- Manufacturer's PIL, Zypadhera® 210 mg, 300 mg and 405 mg powder and solvent for prolonged-release suspension for injectionEli Lilly and Company Limited, The electronic Medicines Compendium. Daté de janvier 2021.
- Médicaments Complet BNF 89ème éditionBritish Medical Association et Royal Pharmaceutical Society of Great Britain, Londres.
Historique de l'article
Les informations contenues dans cette page sont rédigées et évaluées par des cliniciens qualifiés.
Date limite de la prochaine révision : 11 décembre 2025
12 Dec 2022 | Dernière version
20 Aug 2010 | Publié à l'origine
Auteur: :
Helen Allen, MPharm

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