Médicament contre la diarrhée
Revu par Dr Colin Tidy, MRCGPDernière mise à jour par Dr Toni Hazell, MRCGPLast updated 26 mars 2023
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Les médicaments contre la diarrhée (médicaments utilisés pour soulager les symptômes de la diarrhée) réduisent le nombre de fois où vous devez aller aux toilettes lorsque vous avez une diarrhée aiguë. Le médicament le plus couramment utilisé est le lopéramide. Vous pouvez l'acheter dans votre pharmacie locale ou l'obtenir sur ordonnance de votre médecin. La plupart des gens n'ont besoin de prendre ces médicaments que pendant quelques jours et ils ne sont pas nécessaires pour chaque maladie diarrhéique. Les enfants de moins de 12 ans ne doivent pas prendre de médicaments contre la diarrhée sauf si leur médecin leur a dit de le faire.
At a glance
Diarrhoea medicines reduce how often you need to go to the toilet.
Antimotility medicines like loperamide work by slowing gut movement.
These medicines are generally not advised for children under 12 years.
Most acute diarrhoea gets better on its own without medicine.
Possible side-effects include constipation, dizziness, and headaches.

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Qu'est-ce que diarrhée medicine?
Médicament contre la diarrhée is used to reduce the number of trips that you need to make to the toilet when you have diarrhoea. Two main types of diarrhoea medicines are used to treat diarrhoea. These are called antimotility medicines and bulk-forming agents:
Antimotility medicines
This type of diarrhoea medicine is used to treat acute diarrhoea. They include:
Codeine phosphate.
Co-phenotrope.
Loperamide.
Kaolin and morphine mixture.
The most commonly used antimotility medicine is loperamide (Imodium®). Kaolin and morphine mixture is very rarely used to treat diarrhoea nowadays. Antimotility medicines are generally not advised for children under the age of 12 and is only available to buy over the counter for those aged 12 or over.
Remplacement de fluides
It is important to remember that diarrhoea medicines are not the only treatments used for diarrhoea. The most important treatment is fluid replacement. See separate leaflets called Diarrhée aiguë chez l'enfant, and Diarrhée.
The rest of this leaflet deals only with antimotility medicines when they are used to ease the symptoms of acute diarrhoea. For information on bulk-forming agents, see separate leaflet called Irritable Bowel Syndrome.
How do antimotility diarrhoea medicines work?
Retour au sommaireAntimotility medicines work by slowing down the movement of your gut, which reduces the speed at which the contents pass through. Food remains in your gut for longer and this allows more water to be absorbed back into your body. This results in firmer stools that are passed less often.
Antimotility medicines reduce the number of times you need to go to the toilet. This can be helpful in allowing you to continue your normal activities, or if you need to travel anywhere. However, there is no convincing evidence that they reduce the duration of the diarrhoea. Most cases of acute diarrhoea get better on their own in exactly the same amount of time, whether you take any medicines or not.
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Which antimotility medicines are normally used to treat acute diarrhoea?
Retour au sommaireLoperamide is the most commonly used antimotility medicine for acute diarrhoea. It is thought to be the safest and most effective antimotility medicine. Co-phenotrope et codéine are used much less often than loperamide.
As discussed above, kaolin and morphine mixture is an older treatment for acute diarrhoea and is very rarely used nowadays.
When should I take an antimotility diarrhoea medicine?
Retour au sommaireFor most adults and children older than 12 years, antimotility medicines are usually not necessary when they have a bout of diarrhoea. However, some people may wish to reduce the number of trips that they need to make to the toilet. For example, if you have to make an essential journey, taking antimotility medicines may help to make this possible.
Children should not be given antimotility medicines. This is because some children have had very serious side-effects after they have taken these medicines.
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How should I take antimotility diarrhoea medicines?
Retour au sommaireThe following directions are for adults only:
Loperamide - the adult dose of this is two capsules at first. This is followed by one capsule after each time you pass some diarrhoea, up to a maximum of eight capsules in 24 hours.
Co-phenotrope - the adult dose is four tablets at first. Six hours later, take two more tablets. After that, take two tablets every six hours.
Codeine phosphate - for adults, the usual dose is one 15 mg tablet, up to four times a day.
Quelle est la durée habituelle du traitement ?
Most people only need to take an antimotility medicine for a few days. In general, you should not take these medicines for longer than five days unless your doctor has told you to do so.
Where can I buy diarrhoea medicine?
Retour au sommaireYou can buy loperamide and co-phenotrope from your local pharmacy. You can also obtain both of these medicines from your doctor, on prescription. Codeine phosphate is only available from your doctor, on a prescription.
You can only buy kaolin and morphine mixture from your local pharmacy, but quite a few pharmacies do not keep this medicine any more.
Antisecretory medicines are only available from your doctor, on prescription.
Diarrhoea medicine side-effects
Retour au sommaireThe most commonly reported adverse effects of antimotility diarrhoea medicines are:
Excessive farting (breaking wind).
Drowsiness (If this happens, do not drive and do not use tools or machines).
Rare symptoms you may experience are:
Éruptions cutanées.
Itchy skin.
Some children have very serious side-effects after they have taken these medicines - for example:
A condition where part of the gut dies (necrotising enterocolitis).
Confusion.
Depressed breathing.
Coma.
Some children have died after taking these medicines - this is very rare. However, this is why these medicines are not recommended for children.
For a full list of side-effects see the leaflet that comes with your medicine.
Who cannot take diarrhoea medicines?
Retour au sommaireYou should not take diarrhoea medicine if:
You are younger than 12 years of age (unless prescribed by your doctor)
You have blood or mucus in the stools (faeces), and a température élevée (fièvre).
You have tummy (abdominal) distention.
You have inflammation of the gut (active ulcerative colitis).
You have inflammation of the gut caused by antibiotics (antibiotic-associated colitis).
What is acute diarrhoea?
Retour au sommaireDiarrhoea is the passing of frequent loose or liquid stools (faeces). When this change to the stools starts suddenly and lasts for less than two weeks, the condition is known as acute diarrhoea. If it lasts more than two weeks, it is called persistent diarrhoea. If it lasts more than four weeks it is called chronic diarrhoea. There are a number of causes of acute diarrhoea:
Une infection de l'intestin est la cause la plus courante. On l'appelle diarrhée infectieuse aiguë. De nombreuses bactéries, virus et autres germes peuvent provoquer la diarrhée. Parfois, les germes proviennent d'aliments infectés (intoxication alimentaire). Infected water is a cause in some countries. Sometimes it is just 'one of those germs going about'. Viruses are easily spread from one person to another by close contact, or when an infected person prepares food for others.
Other causes are uncommon and include side-effects from some medicines, food allergy et l'anxiété.
Gut disorders that cause chronic diarrhoea may be mistaken for acute diarrhoea when they first begin - for example, diarrhoea caused by la colite ulcéreuse.
Usually no treatment is required when you have acute diarrhoea, other than drinking plenty of fluids.
Voir les brochures séparées intitulées Diarrhée et Diarrhée aiguë chez l'enfant.
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Vérifiez les interactions possibles entre les médicaments, les compléments et les aliments avant de les prendre ensemble.
Questions fréquemment posées
Can I give these medicines to my children?
Antimotility medicines are generally not advised for children under the age of 12. Only those aged 12 or over can buy loperamide over the counter. Some children have experienced very serious side-effects, including a condition where part of the gut dies, confusion, depressed breathing, and coma, and in rare cases, even death, which is why these medicines are not recommended for children.
How long do antimotility medicines take to work?
The article details the dosage instructions for various antimotility medicines, including an initial dose, and subsequent doses after passing diarrhoea or at regular intervals. However, it does not specify how quickly the medicines start to reduce the frequency of bowel movements. It states that they work by slowing gut movement to allow more water to be absorbed, which results in firmer stools passed less often.
What's the difference between fluid replacement and diarrhoea medicine?
Fluid replacement is considered the most important treatment for diarrhoea. Diarrhoea medicines, specifically antimotility medicines, work by slowing down your gut to reduce how often you need to go to the toilet and make stools firmer. They do not shorten how long the diarrhoea lasts, whereas fluid replacement addresses the loss of liquids from your body.
If these medicines reduce the number of toilet trips, do they also make my diarrhoea go away faster?
Antimotility medicines are helpful for reducing the number of times you need to go to the toilet, which can be convenient for continuing normal activities or when travelling. However, there is no convincing evidence that they reduce the duration of the diarrhoea. Most cases of acute diarrhoea resolve on their own in the same amount of time, regardless of whether you take these medicines.
Can I use these medicines if I have blood in my stools?
No, you should not take diarrhoea medicine if you have blood or mucus in your stools and a high temperature (fever).
What should I do if I experience side-effects from these medicines?
If you think you have had a side-effect to one of your medicines, you can report this using the Yellow Card Scheme online at www.mhra.gov.uk/yellowcard. You will need to provide basic information about the side-effect, the medicine you think caused it, the person affected, and your contact details.
Are there other types of diarrhoea medicine mentioned in the article?
Yes, the article mentions two main types of diarrhoea medicine: antimotility medicines and bulk-forming agents. It also briefly refers to antisecretory medicines. This leaflet specifically deals with antimotility medicines, and points to separate leaflets for information on bulk-forming agents and fluid replacement.
Lectures complémentaires et références
- Diarrhée et vomissements chez les enfants de moins de 5 ans; Ligne directrice clinique NICE (avril 2009; mise à jour octobre 2022).
- Formulaire National Britannique (BNF); Services de Preuves NICE (accès réservé au Royaume-Uni)
- Diarrhée - évaluation chez l'adulte; NICE CKS, novembre 2023 (accès réservé au Royaume-Uni)
- Boland A, Tunnard GJ, Bazaz R; Over-the-counter kaolin and morphine: two hazards in one. BMJ Case Rep. 2010;2010:bcr07.2009.2117. doi: 10.1136/bcr.07.2009.2117. Epub 2010 Mar 26.
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About the author

Jenny Whitehall
BSc (Hons), Diploma in Pharmacy Practice
About the reviewerView full bio

Dr Colin Tidy, MRCGP
Médecin généraliste, Auteur médical
MBBS, MRCGP, MRCP (Paediatrics), DCH
Dr Colin Tidy is an NHS Doctor, based in Oxfordshire.
Historique de l'article
Les informations sur cette page sont rédigées et examinées par des cliniciens qualifiés.
Prochaine révision prévue : 24 mars 2028
26 mars 2023 | Dernière version
20 Apr 2012 | Publié à l'origine
Écrit par :
Jenny Whitehall

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