Perte de poids involontaire
Revu par Dr Toni Hazell, MRCGPDernière mise à jour par Dr Caroline Wiggins, MRCGP Last updated 10 déc. 2024
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La perte de poids est souvent une question de choix - nous choisissons de changer nos habitudes alimentaires et d'exercice pour devenir plus sains. S'il y a une raison claire et saine, alors la perte de poids est normale. La perte de poids involontaire est différente. C'est lorsque quelqu'un perd du poids sans essayer. Il est important de le signaler à un médecin afin qu'une cause puisse être identifiée. Ce dépliant répertorie certaines des causes les plus courantes de perte de poids involontaire.
At a glance
Unintentional weight loss is losing more than 5% of your body weight without trying.
Many health conditions can cause unintentional weight loss, including cancer and diabetes.
Mental health issues like anxiety and depression can also lead to unintentional weight loss.
Some other causes can include problems with food access or difficulty eating.
You should see a doctor if you keep losing weight for no reason.
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Some causes of unintentional weight loss
Weight loss is sometimes the first symptom noticed by the person, relative or friend. However, when carefully questioned by a medical professional, people may realise they have more symptoms in addition to their unintentional weight loss. Weight loss is usually defined as a loss of more than 5% of the person's body weight.
Common causes of unintentional weight loss are listed below. The list is not exhaustive.
Cancer
In the vast majority of cases of cancer, other symptoms will develop before any weight loss occurs. The first signs of cancer depend on the type and site of the cancer. However, occasionally, weight loss is the first symptom that is noticed. Common cancers that cause weight loss include those affecting the pancreas, the oesophagus, the stomach, the bowel et the lung. The blood cancer lymphoma, of which there are several types, can cause unintentional weight loss among other symptoms.
Diabète
Les deux Type 1 et Diabète de type 2 can cause unintentional weight loss. As with all causes of unintentional weight loss, it is important to report this to your doctor, as early diagnosis is important.
Desnxiety and depression
Anxiété et dépression have many symptoms and unintentional weight loss can occur for multiple different reasons. People suffering with these symptoms may experience weight loss or weight gain, for example, some people may respond by comfort eating, whilst others may experience a reduced appetite. Smokers may find they respond by smoking more; nicotine can reduce your appetite, causing weight loss. Some people may resort to alcohol to combat anxiety and this may also be associated with weight loss. Loneliness is a common experience for older adults and can affect a person's mood. Weight loss affecting someone whose mental health is suffering may be the most obvious symptom to family and friends.
Dépendance à l'alcool
Some people who drink a lot of alcohol may struggle to look after themselves well, which can cause them to lose weight. Family and friends may show concern about weight loss and not be aware that the person has an alcohol problem.
Hyperthyroïdie
Hyperthyroïdie occurs when the thyroid gland produces too much of a hormone called thyroxine. This condition is also known as an overactive thyroid. The extra thyroxine causes many of your body's functions to speed up. This often causes many symptoms affecting different parts of the body. In the early stages of hyperthyroidism some people actually feel well and full of energy and don't realise they have a problem despite their weight loss.
Persistent (chronic) infection or inflammation
It would be unusual not to have other symptoms with a chronic infection. But, occasionally, the first symptom that is noticed with infections such as la tuberculose ou VIH is weight loss. Hookworm infection of the gut is another example where weight loss may be the first indication of disease. Hookworm is a very common problem worldwide (but rare in the UK). Likewise, there are various conditions that cause persistent inflammation of a part or parts of the body. Again, other symptoms would be usual. However, sometimes an inflammatory condition such as polymyalgia rheumatica may make you feel vaguely unwell and lose weight prior to other symptoms developing.
Malabsorption syndromes
There are various diseases that can affect the way food is absorbed and taken into the body from the gut. These would normally cause gut symptoms such as diarrhoea and abdominal pain. However, weight loss may be the first symptom noticed. Examples include maladie cœliaque, maladie de Crohn et la colite ulcéreuse.
Démence
People with démence may struggle to look after themselves well and lose weight as a result. There can be many reasons for this. In older adults, weight loss may sometimes be the first symptom friends or family notice.
Troubles alimentaires
In conditions such as anorexie, a person usually knows they are tightly controlling their diet and exercise and are actively trying to lose weight. However, this may be very carefully hidden from friends and family and may not be divulged even to the doctor.
Side-effects from medication
Sometimes medication may cause side-effects resulting in weight loss. For example, some medicines may cause a loss of appetite, or a bouche sèche. Some cause brûlures d'estomac or give a mild tummy discomfort. Others may affect the sense of taste or smell, or make people feel sick. Any of these side-effects could affect eating habits and result in weight loss.
Other common causes
There are many reasons a person can lose weight unintentionally, and they are not all because of specific health conditions. Common issues such as lack of money, lack of access to food, difficulty buying and cooking food or difficulty eating can all cause unintentional weight loss. At each of these stages there are many, wide ranging causes which can result in unintentional weight loss. For example difficulty eating can be due to having a problem in your mouth or any condition affecting your ability to accurately place food in your mouth.
Quand consulter un médecin
Retour au sommaireIf you keep losing weight for no reason, see a doctor. This is because, as a general rule, the earlier a serious problem is diagnosed, the better the chance that treatment may improve the outlook (prognosis).
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What assessment and tests may be done?
Retour au sommaireYour doctor is likely to ask various questions. He or she may actually uncover other symptoms that you were either unaware of or did not think were significant. He or she may also examine you. Tests, such as analyses de sang, may or may not be appropriate. Following a doctor's assessment, the likely cause may be clear or you may require more investigations. Your doctor will advise on what is needed depending on what they think is causing the weight loss.
Quel est le traitement ?
Retour au sommaireThe treatment depends on the cause. See individual leaflets on the various diseases that can cause weight loss. The conditions above are not an exhaustive list.
Patient picks for Obésité et perte de poids

Mode de vie sain
Obésité et perte de poids
Si vous êtes en surpoids ou obèse, vous avez un risque accru de développer divers problèmes de santé, notamment le cancer, le diabète et les maladies cardiaques. Même une perte de poids modérée peut contribuer à réduire vos risques pour la santé. La meilleure chance de perdre du poids et de le maintenir est de s'engager à changer de mode de vie. Cela inclut une alimentation saine et une activité physique régulière.
par Dr Doug McKechnie, MRCGP

Mode de vie sain
Enquête de recherche sur l'injection pour la perte de poids
Nous menons une courte enquête de recherche pour mieux comprendre les expériences, les opinions et les besoins d'information des personnes concernant les injections pour la perte de poids, parfois appelées injections amincissantes. Ces médicaments sont de plus en plus discutés au Royaume-Uni, mais les expériences d'accès, d'utilisation et de soutien varient considérablement. L'objectif de cette enquête est de recueillir des insights concrets pour améliorer la manière dont le soutien et l'information sur la perte de poids sont fournis. L'enquête prend environ 2 à 3 minutes à compléter. Ouvrez la calculatrice.
Questions fréquemment posées
What specifically is meant by 'unintentional weight loss'?
Unintentional weight loss is typically defined as losing more than 5% of your body weight without actively trying to do so. It is often noticed by the individual themselves, a relative, or a friend.
Can common mental health issues like anxiety and depression lead to significant weight loss?
Yes, both anxiety and depression can cause unintentional weight loss for various reasons. While some individuals might gain weight through comfort eating, others may experience a reduced appetite. Factors like increased smoking (nicotine reduces appetite) or alcohol consumption to cope with anxiety can also contribute to weight loss.
I'm an older adult and my family has noticed I'm losing weight, but I feel fine. Is this something to worry about?
For older adults, weight loss can sometimes be an early sign of conditions like dementia, where individuals may struggle to care for themselves adequately. Also, loneliness, which is common in older adults, can affect mood and lead to weight loss. Even if you feel well, unintentional weight loss in older adults can be a significant symptom.
How can medication side effects lead to losing weight?
Some medications can cause side effects that impact eating habits, leading to weight loss. These can include a loss of appetite, dry mouth, heartburn, mild stomach discomfort, changes in taste or smell, or feelings of nausea. Any of these can reduce how much you eat and result in weight loss.
Beyond medical conditions, what other everyday factors can cause unintentional weight loss?
Unintentional weight loss isn't always due to specific health conditions. Practical issues such as a lack of money, difficulty accessing food, challenges with buying or cooking meals, or problems with eating itself (like oral health issues or conditions affecting the ability to get food into your mouth) can all contribute to losing weight.
Lectures complémentaires et références
- Cancer suspecté : reconnaissance et orientation; Directive NICE (2015 - dernière mise à jour avril 2026)
- Cao Y, Hardy R, Wulaningsih W; Associations of medical conditions, lifestyle and unintentional weight loss in early old age: The 1946 British Birth Cohort. PLoS One. 2019 Apr 9;14(4):e0211952. doi: 10.1371/journal.pone.0211952. eCollection 2019.
- CKS Malnutrition. February 2024 (UK Access only)
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About the authorView full bio

Dr Caroline Wiggins, MRCGP
Médecin généraliste, Auteur médical
MBBS Honours (with Distinction), MRCGP (2016), MSc.SEM (with Distinction), BSc (Hons)
Dr Caroline Wiggins is a GP locum currently in the South-West of England.
About the reviewerView full bio

Dr Toni Hazell, MRCGP
MBBS, BSc, MRCGP, DFSRH, Dip GU med, DRCOG, DCH (London, UK, 2000)
Dr. Toni Hazell qualified from St. Mary’s Hospital Medical School and did her VTS at Northwick Park Hospital.
Historique de l'article
Les informations sur cette page sont rédigées et examinées par des cliniciens qualifiés.
Prochaine révision prévue : 9 déc. 2027
10 déc. 2024 | Dernière version

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