Can I take Oxypro and Shortec together?
Drug interaction guide
Originally published 25 Jan 2026
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OxyPro and Shortec both contain the same active medicine, oxycodone. Taking them together significantly increases the amount of opioid medication in your body, which can lead to a dangerous overdose. Symptoms include extreme sleepiness, breathing difficulties (slow or shallow breathing), and loss of consciousness.
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Why this happens
This is a 'duplicate therapy' interaction. OxyPro is a long-acting (prolonged-release) version of oxycodone designed to release the drug slowly over 12 hours. Shortec is a short-acting (immediate-release) version designed to work quickly. Because they contain the same drug, taking both increases the total dose and the risk of side effects.
What you should do
Do not take these together unless specifically instructed by your doctor or pain specialist. Usually, a doctor will prescribe OxyPro as a 'background' painkiller and Shortec only as a 'rescue' medicine for sudden, severe pain. You must follow the exact dosage and timing on your prescription labels. If you feel very drowsy or have trouble breathing, seek emergency medical help immediately.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Clause de non-responsabilité
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Historique de l'article
Les informations contenues dans cette page sont rédigées et évaluées par des cliniciens qualifiés.
25 janvier 2026 | Publié à l'origine
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